Q47: Cytotoxic drugs used in skin diseases?

Answer: Following are the article I have found on internet regarding Cytotoxic drugs used in skin diseases.

Article number one:

Toxic epidermal necrolysis: Effector cells are drug-specific cytotoxic T cells

A Nassif, A Bensussan, L Boumsell, A Deniaud, H … – The Journal of Allergy and Clinical Immunology, 2004 – Elsevier
… Immunostaining for granzyme B used 5 μL phycoerythrin-labeled antigranzyme B monoclonal
antibody … Determination of drug-specific cytotoxic activity in …

Article number two:

Drug Specific Cytotoxic T-Cells in the Skin Lesions of a Patient with Toxic Epidermal Necrolysis

A Nassif, A Bensussan, G Dorothée, F Mami-Chouaib … – Journal of Investigative Dermatology, 2002 – nature.com
… Then, we used these stimulated cells to evaluate the molecular basis of target cell
killing. The drug-related cytotoxic effect was not inhibited by a …

Article number three

Treatment of Psoriasis

MW Greaves, GD Weinstein – New England Journal of Medicine, 1995 – content.nejm.org
… etretinate and PUVA has also been used in chronic … Stern RS, Lange R. Non-melanoma skin cancer occurring … The action of cytotoxic drugs on cell proliferation in …

Article number Four

Cytotoxic drugs in the treatment of skin disease.

RP Rapini – Int J Dermatol, 1991 – ncbi.nlm.nih.gov
Int J Dermatol. 1991 May;30(5):313-22. Cytotoxic drugs in the treatment of skin
disease. Rapini RP. Department of Dermatology, University …

Article Number Five

The skin biopsy in the diagnosis of acute graft-versus-host disease in man

GE Sale, KG Lerner, EA Barker, HM Shulman, ED … – American Journal of Pathology, 1977 – ASIP
… of acute graft-versus-host disease (GVHD) using … results of “blind” studies of skin
biopsy specimens … Large doses of cytotoxic drugs and irradiation given before … 

Article Number Six

Drug-Induced Skin Pigmentation: Epidemiology, Diagnosis and Treatment.
O Dereure – American Journal of Clinical Dermatology, 2001 – dermatology.adisonline.com
… 9] Corneal pigmentation is often associated with skin changes and … Cytotoxic Drugs
TOP. … is a very common adverse effect of chemotherapeutic agents used in cancer …

Article Number Seven

Immunosuppressive and cytotoxic drugs in dermatology.
PI Dantzig – Arch Dermatol, 1974 – ncbi.nlm.nih.gov
Immunosuppressive and cytotoxic drugs in dermatology. Dantzig PI. … Methotrexate/
therapeutic use; Procarbazine/therapeutic use; Skin Diseases/drug therapy*; …

Article Number Eight

Rituximab for the treatment of type II mixed cryoglobulinemia
II MC – ARTHRITIS & RHEUMATISM, 2002 – doi.wiley.com
… on systemic autoimmune manifestations, we used the drug … with diffuse purpura, ulcerative
skin lesions on … associated with use of steroids and cytotoxic drugs. …

Article Number Nine

Cytotoxic agents for use in dermatology. I.
CJ McDonald – J Am Acad Dermatol, 1985 – ncbi.nlm.nih.gov
… improved quality of life for patients who have diseases such as … of circumstances,
in the properly monitored patient cytotoxic drugs may be used safely and …

Article Number ten

Management of ‘refractory’skin disease in patients with lupus erythematosus
JP Callen – Best Practice & Research Clinical Rheumatology, 2005 – Elsevier
… have both been used in doses similar to those used for acne … In addition, each of
these drugs is associated with possible … Immunosuppressive and cytotoxic agents. …