Q47: Cytotoxic drugs used in skin diseases?

Apr 8 • Clinical Research Associate, Clinical trail, CRA certification, cracertification_Q&A, cracertification.co.uk • 5621 Views • Comments

Q47: Please find, on the Internet, articles about Cytotoxic drugs used in skin diseases?

Answer: Following are the article I have found on internet regarding Cytotoxic drugs used in skin diseases.

Article number one:

Toxic epidermal necrolysis: Effector cells are drug-specific cytotoxic T cells

A Nassif, A Bensussan, L Boumsell, A Deniaud, H … – The Journal of Allergy and Clinical Immunology, 2004 – Elsevier
 Immunostaining for granzyme B used 5 μL phycoerythrin-labeled antigranzyme B monoclonal
antibody  Determination of drug-specific cytotoxic activity in 

Article number two:

Drug Specific Cytotoxic T-Cells in the Skin Lesions of a Patient with Toxic Epidermal Necrolysis

A Nassif, A Bensussan, G Dorothée, F Mami-Chouaib … – Journal of Investigative Dermatology, 2002 – nature.com
 Then, we used these stimulated cells to evaluate the molecular basis of target cell
killing. The drug-related cytotoxic effect was not inhibited by a 

Article number three

Treatment of Psoriasis

MW Greaves, GD Weinstein – New England Journal of Medicine, 1995 – content.nejm.org
 etretinate and PUVA has also been used in chronic  Stern RS, Lange R. Non-melanoma skin cancer occurring  The action of cytotoxic drugs on cell proliferation in 

Article number Four

Cytotoxic drugs in the treatment of skin disease.

RP Rapini – Int J Dermatol, 1991 – ncbi.nlm.nih.gov
Int J Dermatol. 1991 May;30(5):313-22. Cytotoxic drugs in the treatment of skin
disease. Rapini RP. Department of Dermatology, University 

Article Number Five

The skin biopsy in the diagnosis of acute graft-versus-host disease in man

GE Sale, KG Lerner, EA Barker, HM Shulman, ED … – American Journal of Pathology, 1977 – ASIP
 of acute graft-versus-host disease (GVHD) using  results of “blind” studies of skin
biopsy specimens  Large doses of cytotoxic drugs and irradiation given before  

Article Number Six

Drug-Induced Skin Pigmentation: Epidemiology, Diagnosis and Treatment.
O Dereure – American Journal of Clinical Dermatology, 2001 – dermatology.adisonline.com
 9] Corneal pigmentation is often associated with skin changes and  Cytotoxic Drugs
TOP.  is a very common adverse effect of chemotherapeutic agents used in cancer 

Article Number Seven

Immunosuppressive and cytotoxic drugs in dermatology.
PI Dantzig – Arch Dermatol, 1974 – ncbi.nlm.nih.gov
Immunosuppressive and cytotoxic drugs in dermatology. Dantzig PI.  Methotrexate/
therapeutic use; Procarbazine/therapeutic use; Skin Diseases/drug therapy*; 

Article Number Eight

Rituximab for the treatment of type II mixed cryoglobulinemia
II MC – ARTHRITIS & RHEUMATISM, 2002 – doi.wiley.com
 on systemic autoimmune manifestations, we used the drug  with diffuse purpura, ulcerative
skin lesions on  associated with use of steroids and cytotoxic drugs

Article Number Nine

Cytotoxic agents for use in dermatology. I.
CJ McDonald – J Am Acad Dermatol, 1985 – ncbi.nlm.nih.gov
 improved quality of life for patients who have diseases such as  of circumstances,
in the properly monitored patient cytotoxic drugs may be used safely and 

Article Number ten

Management of ‘refractory’skin disease in patients with lupus erythematosus
JP Callen – Best Practice & Research Clinical Rheumatology, 2005 – Elsevier
 have both been used in doses similar to those used for acne  In addition, each of
these drugs is associated with possible  Immunosuppressive and cytotoxic agents. 

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