Why are hormones important?

Mar 25 • Pharmacy • 1172 Views • Comments

Hormones are secreted by the endocrine system & used at the cellular level for communication between body tissues including the brain, organs, other glands, muscles and other tissues of the body.
Our growth, mood, digestion, respiration, sense of thirst and hunger, sexual functions, fat metabolism and most other bodily functions are all triggered by hormones.

The amount of hormone released or secreted by the endocrine glands is determined by the bodies need for that particular hormone at a given time. Once the hormone is secreted into the circulatory system it transported by the blood to all areas of the body but only specific target cells react to their presence.

Importance of hormones:
Growth hormone is a protein that stimulates the growth of bones, muscles, and other organs by promoting protein synthesis. This hormone drastically affects the appearance of an individual because it influences height. If there is too little growth hormone in a child, that person may become a pituitary dwarf of normal proportions but small stature. An excess of the hormone in a child results in an exaggerated bone growth, and the individual becomes exceptionally tall or a giant.
Thyroid-stimulating hormone, or thyrotropin, causes the glandular cells of the thyroid to secrete thyroid hormone. When there is a hypersecretion of thyroid-stimulating hormone, the thyroid gland enlarges and secretes too much thyroid hormone.
Adrenocorticotropic hormone reacts with receptor sites in the cortex of the adrenal gland to stimulate the secretion of cortical hormones, particularly cortisol.

Gonadotropic hormones react with receptor sites in the gonads, or ovaries and testes, to regulate the development, growth, and function of these organs.

Prolactin hormone promotes the development of glandular tissue in the female breast during pregnancy and stimulates milk production after the birth of the infant.

Antidiuretic hormone promotes the reabsorption of water by the kidney tubules, with the result that less water is lost as urine. This mechanism conserves water for the body. Insufficient amounts of antidiuretic hormone cause excessive water loss in the urine.

Oxytocin causes contraction of the smooth muscle in the wall of the uterus. It also stimulates the ejection of milk from the lactating breast.

Thyroid hormones
About 95 percent of the active thyroid hormone is thyroxine, and most of the remaining 5 percent is triiodothyronine. Both of these require iodine for their synthesis. Thyroid hormone secretion is regulated by a negative feedback mechanism that involves the amount of circulating hormone, hypothalamus, and adenohypophysis.
If there is an iodine deficiency, the thyroid cannot make sufficient hormone. This stimulates the anterior pituitary to secrete thyroid-stimulating hormone, which causes the thyroid gland to increase in size in a vain attempt to produce more hormones. But it cannot produce more hormones because it does not have the necessary raw material, iodine. This type of thyroid enlargement is called simple goiter or iodine deficiency goiter.
Calcitonin is secreted by the parafollicular cells of the thyroid gland. This hormone opposes the action of the parathyroid glands by reducing the calcium level in the blood. If blood calcium becomes too high, calcitonin is secreted until calcium ion levels decrease to normal.

The adrenal cortex consists of three different regions, with each region producing a different group or type of hormones. Chemically, all the cortical hormones are steroid.

Mineralocorticoids are secreted by the outermost region of the adrenal cortex. The principal mineralocorticoid is aldosterone, which acts to conserve sodium ions and water in the body.

Glucocorticoids are secreted by the middle region of the adrenal cortex. The principal glucocorticoid is cortisol, which increases blood glucose levels.

The third group of steroids secreted by the adrenal cortex is the gonadocorticoids, or sex hormones. Male hormones, androgens, and female hormones, estrogens, are secreted in minimal amounts in both sexes by the adrenal cortex, but their effect is usually masked by the hormones from the testes and ovaries. In females, the masculinization effect of androgen secretion may become evident after menopause, when estrogen levels from the ovaries decrease.

The adrenal medulla develops from neural tissue and secretes two hormones, epinephrine and norepinephrine. These two hormones are secreted in response to stimulation by sympathetic nerve, particularly during stressful situations. A lack of hormones from the adrenal medulla produces no significant effects. Hypersecretion, usually from a tumor, causes prolonged or continual sympathetic responses.

Male sex hormones, as a group, are called androgens. The principal androgen is testosterone, which is secreted by the testes. A small amount is also produced by the adrenal cortex. Production of testosterone begins during fetal development, continues for a short time after birth, nearly ceases during childhood, and then resumes at puberty. This steroid hormone is responsible for:
· The growth and development of the male reproductive structures
· Increased skeletal and muscular growth
· Enlargement of the larynx accompanied by voice changes
· Growth and distribution of body hair
· Increased male sexual drive

Testosterone secretion is regulated by a negative feedback system that involves releasing hormones from the hypothalamus and gonadotropins from the anterior pituitary

Two groups of female sex hormones are produced in the ovaries, the estrogens and progesterone. These steroid hormones contribute to the development and function of the female reproductive organs and sex characteristics. At the onset of puberty, estrogens promotes:
· The development of the breasts
· Distribution of fat evidenced in the hips, legs, and breast
· Maturation of reproductive organs such as the uterus and vagina
Progesterone causes the uterine lining to thicken in preparation for pregnancy. Together, progesterone and estrogens are responsible for the changes that occur in the uterus during the female menstrual cycle.

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