Tuesday, December 24, 2024
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Why Popping Your Neck is Harmful ?

SUMMARY: If you often crack or pop your neck yourself, it probably means that the joints are hypermobile. The ligaments are a bit lax so the joints move a little more than they should. In response, the muscles tighten up to stabilize the joints. This makes your neck feel tight and makes you want to crack it. When you do that, the muscles are momentarily stretched, they relax somewhat, and you feel better for a while. But when you crack your neck you also stretch the loose ligaments further which makes the muscles tighten up again. It’s a vicious cycle.

(Hypermobility should not be confused with clinical instability.)

What’s the Real Problem and What Can You Do About It?

The scenario goes something like this: You’re under a lot of stress and your neck feels tight. This morning you drove all over town meeting with clients. You were late for a meeting and the client left before you could get there. The next client stood you up. Now you’re back at the office staring at your computer screen. Your company just upgraded and you can’t get the program to do what it’s suppose to do. Your neck feels like it’s in a vice. Without giving it much thought you put one hand on the back of your head, cup your chin in the palm of the other hand, and twist sharply. Your neck emits popping sounds like a string of firecrackers on Chinese New Year. You twist in the other directions, hearing and feeling another series of cracks. Aaahh … that’s better! But soon the stress mounts again, tension builds, and you find yourself twisting your neck again. Each time the results are less satisfying. By the end of the day you feel like you’ve been through the ringer, and so does your neck.

If you are a chronic neck cracker you are probably doing more harm than good. What happens when someone repeatedly manipulates his or her neck? In order to understand how this can be harmful, it first helps to have some knowledge of normal joint function. Here are the fundamentals:

1. Joints move. Okay, you knew that already. The point is that your spine is made up of many vertebrae, each of which articulates (forms joints with) the vertebra above and the vertebra below. The joints in the spine do not have as great a range of motion as do the larger and more mobile joints of the shoulders, elbows, hips, and knees, but because there are 24 moveable segments in the spine, the combined motion of these joints allows us to bend forward and touch our toes (some of us, anyway), look over our shoulders to back the car out of the driveway, and perform nearly all of our daily activities. Without spinal motion people would look like the Tin Man before he found his oil can. Joints move.

2. Normal joints have normal motion. This may sound like another no-brainer, but neck-crackers have a problem with normal joint motion. There are four phases of motion: active, passive, paraphysiologic – where the “pop” occurs during manipulation – and sprain – where ligaments are injured. This is illustrated in the figure below.

Active motion is the range in which a person can move a joint unaided. For example, wave your index finger up and down. That’s the active range of your second metacarpophalangeal joint (the big knuckle). Now use the fingers of your other hand to move the index finger up and down passively. The passive range of motion should be greater than the active range. Joint mobilization, a treatment used by physical therapists and less commonly by chiropractors, is movement within the passive range of motion.

3. Why joints pop. Movement through the paraphysiologic zone, the Twilight Zone of joint motion, occurs when the passive range is exceeded but before actual damage can occur. Paraphysiologic motion involves the “play” of a joint, not just further passive motion. This springiness you feel in your knuckle when you gently tug on a finger or push the finger backward to the endrange of passive motion is there because the ligaments have a little give built into them. In the paraphysiologic zone the surfaces of each bone – which don’t actually quite touch in a normal joint – move apart slightly further. A sudden and quite temporary vacuum occurs which is just as suddenly filled by gas which has been, up until that moment, saturated in the joint fluid. A popping or cracking noise is produced. This exchange of gas and fluid is called cavitation. It is similar to popping your cheek with your finger; when you push your fingertip out of your mouth quickly, air rushes in to the space suddenly created and makes a pop!

4. The bad news for “self-manipulators.” If you are a chronic neck-popper, you are very likely stretching the ligaments which support and stabilize your neck joints. Stretched ligaments result in a condition called hypermobility in which the joints lose their natural springy end play. To someone skilled at feeling joint motion, like a chiropractor, this loss of springiness can be detected. It is sometimes jokingly referred to as “floppy disc syndrome,” although the discs in the neck are not directly affected. As the ligaments become more lax, the small muscles that connect one vertebra to the next become tight. They have to work harder to make up for the loss of stability due to the lax ligaments. This makes your neck feel tight. As the muscle tension builds and your neck becomes more and more uncomfortable, you feel the urge to manipulate your neck. CRACK! The muscles are stretched, they relax, and you feel some relief. Of course, this manipulation also stretched those already loose ligaments, and the vicious cycle starts over again.

Hypermobility can be congenital (i.e., hereditary) or acquired. Teens tend to have hypermobile spinal joints. This is normal and will usually resolve as the skeleton and supporting tissues finish growing. However, if neck cracking becomes a habit, then the problem can continue into adulthood. Clinical evidence suggests that hypermobile spinal joints become arthritic at a faster rate than normal joints. Hypermobility can also result from injuries such as whiplash, or it can be self-inflicted. Some popping in the back or neck occurs spontaneously with movement and may be normal.

Treatment: Chiropractors treat hypermobility with strengthening exercises. If the ligaments are weak and the muscles have to work harder, they will be less tense if they are stronger. Strong muscles don’t have to work as hard as weak muscles, so there is less tension. Hypermobility is also treated with spinal adjustments, a form of manipulation. Although this would seem to be contradictory, sometimes hypermobility can be a compensation for restricted or fixated joints elsewhere in the spine. The adjustments are given only to these joints, not the hypermobile ones.

Of course, the best thing to do is to STOP POPPING YOUR NECK. That’s it. Just don’t do it. Most people who “go cold turkey” will feel worse for a time. But even if no other treatment is given, you will probably feel much better after two or three weeks.

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How to Keep Bad Moods From Taking You Over

Well, it happens sometimes.

I find myself in a lousy mood. Hard to say where it started, but it certainly has something to do with not getting much sleep Saturday night. I had big plans for Sunday, but the day was compromised by my zombie state. I think my IQ shrunk about thirty points from normal, for the whole day. I did everything wrong. I cooked badly, I conversed badly, I wrote badly.

My funk cruised on through today too. Work was a real slog, even though everything I needed to do was easy. I was working outside, which I normally enjoy. I wanted to go home. I wanted some Belgian chocolate. I wanted the Sun to f**k off.

Today I was going to write a more in-depth post on another topic, but when I sat down to do it, it was like pulling teeth. I know I could have churned out something, but it would have been a crusty, callous little post. I just couldn’t resonate with what I was had planned to write about, so I asked myself The Big Question: “Given my dreams and goals in life, what is honestly the smartest way to spend my next 30 minutes?” My answer came: Write about what you can resonate with right now. So I decided to put my crap mood to good use.

The Nature of the Beast

Low moods are a bizarre animal. They’re like a nasty drug that hijacks your thoughts and robs you of your intuition and perspective. They make bad things look bigger and good things look smaller. It’s as if they have their own demented gravity, drawing annoyances and inconveniences — not to mention the crappy moods of other people — out of the woodwork towards you. Foul moods don’t seem to emanate from any particular source, or line of thought, they just waft into your headspace when you’re disappointed and vulnerable. They cast a pervasive dullness on the people you meet and the places you visit, and the things you think about.

Mine is currently sucking the excitement out of certain upcoming events that normally thrill me to think about.  My big travel plans, my growing new blog (which is, as I type, having its busiest traffic day ever) and my newly blossoming friendships are all lending me very little joy at this particular moment. Because my mood sucks. C’est la vie.

Thankfully I’ve learned to recognize what it means to be in a bad mood, and usually I can remember what to do about it. Above all else, a bad mood means I’ve lost perspective. I can’t see clearly, and I know it.

In a bad mood, the thinking mind sticks around (sometimes it even goes into overdrive) but wisdom seems to slink away when you’re not looking. The highest properties of the mind — intuition, compassion, patience and acceptance — slip quietly out the door like bored houseguests. Today, even when I looked for them in my head, even when I knew they were exactly what I needed to get back on track, I just couldn’t locate them.

Simply understanding this “wisdom-loss” phenomenon inherent to bad moods goes a long way. It explains why everything looks so bad. Perspective becomes impaired, but you can’t actually see that while it is happening. You just have to remember that bad moods bend things towards the negative end.

Part of the impairment is that your mind tells you your negative outlook is completely warranted. When you simply remind yourself that you are temporarily missing certain important mental qualities, you can consciously defer any bigger decisions and actions until you have your whole mind working for you again.

The most important thing I ever learned about moods is this:

Your mood does not represent the state of your life, but it pretends to.

Looking objectively at the state of my life right now, it’s spectacular. I’m young, in good health, I have friends coming out of my ears, I’ve finally got a long-needed creative outlet, I’m gearing up for an epic trip this fall, I’m generally unfettered by debt, and I even don’t mind my day job. But my bad mood doesn’t care. It doesn’t see any value in those things. I feel no swell of excitement when I think about them. I still want to lay down and put my head under a pillow.

Emotionally, it feels like my dreams have plowed into the guardrail. Bottomed out and spewing smoke. Wrecked. In the past I would have trusted this feeling, and made decisions based on it. I would have pictured an unrealistically bleak future, convinced myself it was well on its way towards me, and panicked accordingly. But now I know bad moods make for unreliable assessments. Tomorrow, all the same things will look different. This I know from experience.

The Role of Physical Interference

I have learned a lot about how to be calm and patient under normal circumstances, but I find physical interference erodes this very quickly. By physical interference I’m referring to any physical discomfort (such as an upset stomach, excessive heat or cold, or hunger pangs) or any mental impairment (such as lack of sleep or the effects of alcohol.) When your body is screaming for something, patience and acceptance are much more difficult to achieve.

Have you ever had someone trap you in a long-winded conversation when you have to pee really bad? No matter how patient a listener you are normally, you probably aren’t going to be too receptive. Physical bodily distress overrides all of your other priorities. It’s just mother nature looking out for you. No time for the luxury of a good mood when you’ve neglected your body.

For this reason, I found it very difficult to be mindful and appreciative at work today because my head was sluggish and heavy and I desperately wanted to be horizontal. Physical interference will probably undermine pretty much anything you do to recover from your mood, until you can satisfy the body’s needs.

The other day I caught the end of a segment on CBC radio where they were discussing happiness. The guest was familiar to me: blogger Gretchen Rubin, from The Happiness Project. As a parting question, the interviewer asked for the one most important tip she would give people for achieving happiness. Her answer was to get adequate sleep. If I wasn’t convinced then, I am after today. The body’s fundamental needs have to be taken care of before one can hope to be stable emotionally.

Recovering from bad moods

The first step is simply to acknowledge you are in a bad mood. Here’s a litmus test: if you can’t get excited about something you are normally excited about, you’re in a bad mood. Remind yourself that your perspective is currently limited, and that your faculties of wisdom are currently impaired or dormant. Remember that any visions you have of the future are going to look unreasonably bleak, any assessments you make are going to be distorted towards the negative. As a bonus, other people are going to seem more annoying than they really are. So take all your judgments with a grain of salt.

Attending to your body’s needs is a sensible first step to responding to a bad mood. Understand, though, the difference between what your body needs and what your mind wants. Your weary body might want sleep, while your flustered mind wants Häagen-Dazs. There is a fine line between mental wants and bodily needs, but it can be hard to see.

To determine what your body is asking for, focus your attention on the physical sensations in your body: observe what your stomach feels like, what your breathing feels like, what your head feels like. Scan the body by closing your eyes and noticing the sensations. Any needs should become apparent, and while your attention is on your body, your mind will be quiet.

A Warning

It is very tempting (and common) to treat bad moods by indulging one’s wants. The Häagen-Dazs approach is self-comfort, not self-love. Beware of this phenomenon: bad moods make you wanty. I say wanty instead of needy because often wants masquerade as genuine needs.

In my experience, bad moods usually spawn a very strong want for comfort. This can be a spectacularly intense desire — it is crucial to handle it sensibly. If we choose to respond with some sort of indulgence, addiction is a very real danger. Most of us have a favorite way of responding to this comfort-lust, and depending on how conditioned we are to it, it can be a killer.

Some people shop themselves into hopeless debt. Some drink themselves into ruined health and relationships. Some eat until they are ashamed and sick. Some throw tantrums and punch walls. Some stare into the television for four hours straight. All of us do something to respond to the desire for comfort, and most often it has some sort of cost.

Once a pattern emerges, it can become more and more insidious and even completely derail someone’s life. The shame of indulging in a comfort habit can reinforce a bad mood, and very often it becomes self-perpetuating. Lives can be taken over and destroyed by it. Watch an episode of Intervention if you don’t know what that looks like.

Think about how you normally respond to the desire for comfort. What does it cost you? What could you do instead that doesn’t have such a cost?  Bad moods will come and go your whole life. Don’t let them rob you each time. There is no limit to the number of bad moods you can have, so there is no limit to the amount of money, physical health and self-respect you can lose.

Find another way to behave in those situations. Take a walk, visit a friend, pick up a book, work out, go learn something… anything but give up money or health to this bad mood. In any case, indulging the lust for comfort usually just prolongs the funk by making you feel like you need more of that indulgence to push it away again.

Ugly moods pass more quickly when you acknowledge them, let them visit you for a bit, and avoid chasing them away with indulgence. Remember some guidelines: Defer big decisions until you’re in a better headspace. Take all of your assessments — of people and of situations — with a grain of salt. Do not trust any visions you have of the future, or any assessments of your ability, worth or potential. There is just so much there you just can’t see. Beware of assigning blame. Similar to “Don’t drink and drive” is “Don’t fret and decide.” Wait until you sober up. Sleep it off.

The main rule of thumb is this: know it will be gone soon, and do as little harm as possible in the mean time.

And now I feel fine again. Look at that.

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6 Signs of Depression Your Friends Are Too Stupid To See

by: Sophia Walker

As someone who has suffered from depression their entire life, I would submit to you that there are NO signs of depression that are obvious and easy to understand.

I say this because at no point in my life has anyone, not friends nor family nor colleagues nor total strangers ever shown even the tiniest hint of understanding the symptoms of the depression I have suffered from.

For instance, a couple of weeks ago I went with my friend “Steve” to eat at a diner with his family. Completely out of the blue Steve’s father proceeds to tell me “what my problem is.” According to him, I am “unmotivated.” In my own defense, I am not entirely unmotivated; at that moment I was motivated to kick him in the fucking teeth.

Depression has caused people to call me unmotivated, lazy, uncaring, cruel, selfish, stupid and a hypochondriac. The one thing they seem unable to call me is a psychiatrist.

The fact is mental illness, especially depression, is simply not something that most people can even begin to understand. Depression is completely counter-intuitive and as a result utterly insidious.

For example, everyone experiences sadness, but most people can point to an environmental cause for it. Maybe their dog died or they lost their job. But if you take away a cause of sadness that you can easily point to, most people refuse to acknowledge that sadness can even exist. And yet sadness that doesn’t have an easily identifiable cause is a classic symptom of depression. Again, it’s counter-intuitive.

Another even more basic example of the insidious nature of depression is the loss of the will to live. Of course everyone wants to live; survival is a basic human instinct. So most people cannot grasp the concept of not wanting to live, it simply doesn’t seem possible. And yet suicide happens again and again, to the utter shock and amazement of just about everyone.


Black and white photographs are really depressing
 

So let’s have a look at the “6 surprising symptoms of depression” shall we?

1. Achy joints and other unexplained pain
Often people notice that they don’t feel well, or that something hurts and don’t connect it with depression. “But headaches, back pain, stomach aches, and joint discomfort are actually common signs,” says psychiatrist Scott Halztman, MD, medical director of NRI Community Services in Rhode Island. “And they often resolve when the depression gets better.”

Not much I can say on this matter, I suffer from chronic pain all the time. And nobody seems to notice.

2. Gut reaction
Changes in your bowels (constipation or having to use the bathroom more than usual) are telltale signs of anxiety, which in itself is a stealth symptom of depression. This is especially true of women, says Haltzman.

I have an ulcer and a host of other digestive issues I won’t go into. But yeah this is a big one.

3. Diving into work
Some people stop functioning and don’t get out of bed. Others do the opposite, says Philip Muskin, MD, professor of clinical psychiatry at Columbia University, which is one of the screening sites. “Often people push themselves as hard as they can, physically and emotionally—into work, training for a marathon. It’s as if they’re fighting the depression.” While a hard worker might just be trying to score a promotion, Muskin says, when fueled by depression, the drive doesn’t have that clear goal.

If by “work” they mean “blogging,” yeah, I do tend to dive into certain activities with complete abandon.

4. Interviewing, but not getting the job
When you’re trying to get hired, depression is an insidious handicap, leeching you of the energy, warmth, and can-do spirit a person hiring wants to see. You may not realize you’re running on a low battery, but it’s as if the disease creates a palpable apathy. “From the interviewer’s perspective,” says Muskin, “there’s a very real difference when you look somebody in the eye and he doesn’t really look back, or his voice doesn’t have that quality of I’m really excited to be here, because he’s not excited about anything.” Also, Muskin points out, when you’re depressed it’s harder to dress and put yourself together in a way that says, “Hire me.”

I haven’t gotten a job I’ve interviewed for in 15 years.

5. Paranoid thoughts
Haltzman says in about 10 percent of cases, depression may include delusional thoughts. “I had a very bright patient with a PhD,” he says, “and she began to think that someone had planted the wires in her house to spy on her.” The delusions may take the form of thinking you have a fatal illness. Being convinced you have Alzheimer’s, for example, can be a red flag for depression, Haltzman says, because those who actually suffer from it generally aren’t aware they’re losing their memory.

The problem with this one is, I currently or in the past have suffered from 6 of the 10 leading causes of death of Americans. Am I paranoid or a hypochondriac? I think not.

6. Not being in the mood
When interest in sex nosedives for one person in a couple, there are all kinds of reasons that come to mind—age, boredom, medications, and mistresses among them. But Muskin stresses, it’s also a common sign of depression, especially when the man is suddenly unable to perform. “Depression makes you lose interest in a lot of things, including making love. If you notice a change, it’s something to consider.”

Sex? What’s that?

Sorry I really get on my soapbox when it comes to depression.

I am continually shocked by the fact that decent, intelligent and caring people can be so oblivious to the suffering that goes on right under their noses. But again, that just proves my point – that depression is simply not something that can be easily understood.

Depression is real folks, take my word for it.

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What is Social Anxiety?


A woman hates to stand in line in the grocery store because she’s afraid that everyone is watching her. She knows that it’s not really true, but she can’t shake the feeling. While she is shopping, she is conscious of the fact that people might be staring at her from the big mirrors on the inside front of the ceiling. Now, she has to talk to the person who’s checking out her groceries. She tries to smile, but her voice comes out weakly. She’s sure she’s making a fool of herself. Her self-consciousness and anxiety rise to the roof…

Another person sits in front of the telephone and agonizes because she’s afraid to pick up the receiver and make a call. She’s even afraid to call an unknown person in a business office about the electric bill because she’s afraid she’ll be “putting someone out” and they will be upset with her. It’s very hard for her to take rejection, even over the phone, even from someone she doesn’t know. She’s especially afraid to call people she does know because she feels that she’ll be calling at the wrong time — the other person will be busy — and they won’t want to talk with her. She feels rejected even before she makes the call. Once the call is made and over, she sits, analyzes, and ruminates about what was said, what tone it was said in, and how she was perceived by the other person….her anxiety and racing thoughts concerning the call prove to her that she “goofed” this conversation up, too, just like she always does. Sometimes she gets embarrassed just thinking about the call.

A man finds it difficult to walk down the street because he’s self-conscious and feels that people are watching him from their windows.Worse, he may run into a person on the sidewalk and be forced to say hello to them. He’s not sure he can do that. His voice will catch, his “hello” will sound weak, and the other person will know he’s frightened. More than anything else, he doesn’t want anyone to know that he’s afraid. He keeps his eyes safely away from anyone else’s gaze and prays he can make it home without having to talk to anyone.

A man hates to go to work because a meeting is scheduled the next day. He knows that these meetings always involve co-workers talking with each other about their current projects. Just the thought of speaking in front of co-workers raises his anxiety. Sometimes he can’t sleep the night before because of the anticipatory anxiety that builds up. Finally, the meeting is over. A big wave of relief spills over him as he begins to relax. But the memory of the meeting is still uppermost in his mind. He is convinced he made a fool of himself and that everyone in the room saw how afraid he was when he spoke, and how stupid he acted in their presence. At next week’s meeting, the boss is going to be there. Even though this meeting is seven days away, his stomach turns raw with anxiety and fear floods over him again. He knows that in front of the boss he’ll stammer, hesitate, his face will turn red, he won’t remember what to say, and everyone will witness his embarrassment and humiliation. He has seven miserable days of anxiety ahead of him — to think about it, ruminate over it, worry about it, over-exaggerate it in his mind…….again and again and again…..

A student won’t attend her university classes on the first day because she knows that in some classes the professor will instruct them to go around the room and introduce themselves. Just thinking about sitting there, waiting to introduce herself to a roomful of strangers who will be staring at her makes her feel nauseous. She knows she won’t be able to think clearly because her anxiety will be so high, and she is sure she will leave out important details. Her voice might even quiver and she will sound scared and tentative. The anxiety is just too much to bear—so she skips the first day of class to avoid the possibility of having to introduce herself in class.

Another young man wants to go to parties and other social events—indeed, he is very, very lonely—but he never goes anywhere because he’s very nervous about meeting new people. Too many people will be there and crowds only make things worse for him. The thought of meeting new people scares him—will he know what to say? Will they stare at him and make him feel even more insignificant? Will they reject him outright? Even if they seem nice, they’re sure to notice his frozen look and his inability to fully smile. They’ll sense his discomfort and tenseness and they won’t like him — there’s just no way to win — “I’m always going to be an outcast,” he predicts. And he spends the night alone, at home, watching television again. He feels comfortable at home. In fact, home is the only place he does feel completely comfortable. He hasn’t gone anywhere else in twelve years.

In public places, such as work, meetings, or shopping, people with social anxiety feel that everyone is watching, staring, and judging them (even though rationally they know this isn’t true). The socially anxious person can’t relax, “take it easy”, and enjoy themselves in public. In fact, they can never fully relax when other people are around. It always feels like others are evaluating them, being critical of them, or “judging” them in some way. The person with social anxiety knows that people don’t do this openly, of course, but they still feel the self-consciousness and judgment while they are in the other person’s presence. It’s sometimes impossible to let go, relax, and focus on anything else except the anxiety and fear. Because the anxiety is so very painful, it’s much easier just to stay away from social situations and avoid other people altogether.

Many times people with social anxiety simply must be alone—closeted—with the door closed behind them. Even when they’re around familiar people, a person with social anxiety may feel overwhelmed and have the feeling that others are noticing their every movement and critiquing their every thought. They feel like they are being observed critically and that other people are making negative judgments about them.

One of the worst circumstances, though, is meeting people who are “authority figures”. Especially people such as bosses and supervisors at work, but including almost anyone who is seen as being “better” than they are in some respect. People with social anxiety may get a lump in their throat and their facial muscles may freeze up when they meet this person. The anxiety level is very high and they’re so focused on “not failing” and “giving themselves away” that they don’t even remember what was said in the conversation. But later on, they’re sure they must have said the wrong thing…..because they always do.

How is it ever possible to feel “comfortable” or “natural” under these circumstances?

To the person with social anxiety, going to a job interview is pure torture: you know your excessive anxiety will give you away. You’ll look funny, you’ll be hesitant, maybe you’ll even blush, and you won’t be able to find the right words to answer the questions coherently. Maybe this is the worst part of all: You know that you are going to say the wrong thing. You just know it. It is especially frustrating because you know you could do the job well if you could just get past this terrifying and intimidating interview.

Welcome to the world of the socially anxious.

Social anxiety is the third largest psychological problem in the United States today. This type of anxiety affects 15 million Americans in any given year. Unlike some other psychological problems, social anxiety is not well understood by the general public or by medical and mental health care professionals, such as doctors, psychiatrists, psychologists, therapists, social workers, and counselors. In fact, people with social anxiety are misdiagnosed almost 90% of the time. People with social phobia come to our anxiety clinic labeled as “schizophrenic”, “manic-depressive”, “clinically depressed”, “panic disordered”, and “personality disordered”, among other damaging misdiagnoses.

Because few socially-anxious people have heard of their own problem, and have never seen it discussed on any media, such as the television talk shows, they think they are the only ones in the whole world who have these terrible symptoms. Therefore, they must keep quiet about them. It would be awful if everyone realized how much anxiety they experienced in daily life. Then what would people think about them? Unfortunately, without some kind of education, knowledge, and appropriate treatment, social phobia/social anxiety continues to wreak havoc throughout their lives. Adding to the dilemma, when a person with social anxiety finally gets up the nerve to seek help, the chances that they can find it are very, very slim.

Making the situation more difficult is that social anxiety does not come and go like some other physical and psychological problems. If you have social anxiety one day……you have it every day for the rest of your life…..

The feelings I described to you at the beginning of the article are those of people with social anxiety disorder. That is, their symptoms apply to most social events and functions in almost every area of life. I suffered from social anxiety myself for twenty years before I ever saw the term or read about its symptoms in a book. (The first book that specifically dealt with social phobia was not published until the 1990’s.)

As with all problems, everyone with social anxiety has slightly different secondary symptoms. Some people, for example, cannot write in public because they fear people are watching and their hand will shake. Others are very introverted and they find it too difficult to hold down a job. Still others have severe anxiety about eating or drinking in the presence of other people. Some people with social anxiety feel that a certain part of their body (such as the face or neck) are particularly “strange looking” and vulnerable to being stared at. Others experience a muscle spasm (usually around the neck and shoulders) and it becomes the center of their focus —“it’s so embarrassing that if someone sees it I will be humiliated forever!”

One thing that all socially anxious people share is the knowledge that their thoughts and fears are basically irrational. That is, people with social anxiety know that others are really not critically judging or evaluating them all the time. They understand that people are not trying to embarrass or humiliate them. They realize that their thoughts and feelings are somewhat exaggerated and irrational. Yet, despite this rational knowledge, they still continue to feel differently.

It is these automatic “feelings” and thoughts that occur around social situations that must be met and conquered in therapy. Usually these anxious feelings are tied to thoughts that are entwined in a vicious cycle of negative expectations and negative appraisals. It is a catch-22 situation: there is no way out without the appropriate therapy.

Here comes the good part.

How can social anxiety be treated? Many therapeutic methods have been studied, but cognitive-behavioral therapy is the only modality that has been shown to work effectively. In fact, treatment of social anxiety through cognitive-behavioral methods has the capacity to produce long-lasting, permanent relief from the anxiety-laden world of social anxiety.

Social anxiety responds to relatively short-term therapy, depending on the severity of the condition. I have seen significant progress in just twelve individual sessions, although most people respond better with sixteen to twenty-four meetings. To overcome social anxiety, completion of a behavioral therapy group is also essential (when people feel ready for this and not before). 

What socially anxious people do not need is years and years of therapy or counseling. You can’t be “counseled” out of social phobia. In fact, socially anxious people who are taught to “analyze” and “ruminate” over their problems usually make their social anxiety and fears much worse, which in turn leads to depression, which just reinforces the fact that “I will never get better”. (Shudder…this statement does NOT have to be true.)

THERE IS A BETTER LIFE FOR ALL PEOPLE WITH SOCIAL ANXIETY. Without treatment, social anxiety is a torturous and horrible emotional problem; with treatment, its bark is worse than its bite. Add to this that current research is clear that cognitive-behavioral therapy is highly successful in the treatment of social anxiety. In fact, the people who are unsuccessful are the ones who are not persistent in their practice and who won’t stick with simple methods and techniques at home. They are the ones who give up. 

If a person is motivated to end the years and years of crippling anxiety, then cognitive-behavioral treatment provides the methods, techniques, and strategies that come together to lessen the anxiety and make the world a much more enjoyable place. 

Many of us have been through the crippling fears and constant anxiety that social phobia produces — and have come out healthier and happier on the other side. You can too.

—Thomas A. Richards, Ph.D.
Psychologist

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New technology eliminates plant toxins

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Contact: Professor Barbara Halkier
[email protected]
45-26-27-45-25
University of Copenhagen

New technology eliminates plant toxins

Plants produce toxins to defend themselves against potential enemies, from herbivorous pests to diseases. Oilseed rape plants produce glucosinolates to serve this purpose. However, due to the content of glucosinolates, farmers can only use limited quantities of the protein-rich rapeseed for pig and chicken feed. Now, a team of researchers from the University of Copenhagen has developed a method to hinder unwanted toxins from entering the edible parts of the plant. The breakthrough was published today in the prominent scientific journal Nature.

“We have developed an entirely new technology that we call ‘transport engineering’. It can be used to eliminate unwanted substances from the edible parts of crops,” says Professor Barbara Ann Halkier, head of the Center of Excellence for Dynamic Molecular Interactions (DynaMo) at the University of Copenhagen’s Faculty of Science.

The potential for toxin-free oilseed rape as a feed crop

The oilseed rape plant is but one example of a crop whose use will be greatly enhanced thanks to the new technology. Unlike the healthy glucosinolates found in broccoli, oilseed rape additionally produces a glucosinolate that is harmful to most animals when consumed in larger amounts.

This means that protein-rich rapeseed cake produced using the byproduct of rapeseeds pressed for oil, can only be used in limited quantities for pig and chicken feed. Due to this, Northern Europe continues to import large amounts of soy cake for animal feed.

Two transport proteins found

The breakthrough increases the potential of oilseed rape as a commercial animal feed:

“We managed to find two proteins that transport glucosinolates into the seeds of the thale cress plant, a close relative of the oilseed rape. When we subsequently produced thale cress without these two proteins, the remarkable result was that their seeds were completely free of glucosinolates and thus suitable for feed,” emphasises Barbara Ann Halkier.

Worldwide, oilseed rape is the third most widely grown oilseed-producing crop. ‘Transport engineering’, the new technology platform, is so promising that one of the world’s largest companies involved in plant biotechnology – Bayer CropScience – is now negotiating with the University of Copenhagen’s Tech Transfer Unit to collaborate with the research group so as to deploy the new technology and produce an oilseed rape plant with glucosinolate-free seeds. According to Bayer CropScience project leader Peter Denolf such seeds will significantly enhance the use of oilseed rape meal as animal feed and bring along a more sustainable oilseed rape processing procedure.

The research results are the fruit of 16 years of basic research, an excellent example of how basic research can result in new discoveries of direct use for society.

 

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The DOI for the scientific paper published in Nature will be 10.1038/nature11285.

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Sequencing of malaria genomes reveals challenges, opportunities in battle against parasite

Contact: James Devitt
[email protected]
212-998-6808
New York University

Sequencing of malaria genomes reveals challenges, opportunities in battle against parasite

Genetic variability revealed in malaria genomes newly sequenced by two multi-national research teams points to new challenges in efforts to eradicate the parasite, but also offers a clearer and more detailed picture of its genetic composition, providing an initial roadmap in the development of pharmaceuticals and vaccines to combat malaria.

The research appears in two studies published in the latest issue of the journal Nature Genetics. They focus on Plasmodium vivax (P. vivax), a species of malaria that afflicts humans and the most prevalent human malaria parasite outside Africa, and Plasmodium cynomolgi (P. cynomolgi), a close relative that infects Asian Old World monkeys.

“The bad news is there is significantly more genetic variation in P. vivax than we’d thought, which could make it quite adept at evading whatever arsenal of drugs and vaccines we throw at it,” said Professor Jane Carlton, senior author on both studies and part of New York University’s Center for Genomics and Systems Biology. “However, now that we have a better understanding of the challenges we face, we can move forward with a deeper analysis of its genomic variation in pursuing more effective remedies.”

In one study, the researchers examined P. vivax strains from different geographic locations in West Africa, South America, and Asia, providing the researchers with the first genome-wide perspective of global variability within this species. Their analysis showed that P. vivax has twice as much genetic diversity as the world-wide Plasmodium falciparum (P. falciparum) strains, revealing an unexpected ability to evolve and, therefore, presenting new challenges in the search for treatments.

The second study, performed jointly with Professor Kazuyuki Tanabe at Osaka University, Japan, sequenced three genomes of P. cynomolgi. The researchers compared its genetic make-up to P. vivaxand to Plasmodium knowlesi (P. knowlesi), a previously sequenced malaria parasite that affects both monkeys and humans in parts of Southeast Asia.

Their work marked the first time P. cynomolgi genomes have been sequenced, allowing researchers to identify genetic diversity in this parasite. Its similarity to P. vivax means that their results will also benefit future efforts to understand and fight against forms of malaria that afflict humans.

“We have generated a genetic map of P. cynomolgi, the sister species to P. vivax, so we can now push forward in creating a robust model system to study P. vivax,” explained Tanabe. “This is important because we can’t grow P. vivax in the lab, and researchers desperately need a model system to circumvent this.”

 

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Much of the work occurred under a seven-year grant from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The funding has established 10 International Centers of Excellence for Malaria Research (ICEMR). Carlton is heading an ICEMR based in India, where malaria – and P. vivax in particular — is a significant public health burden. A particular aim of this Center of Excellence is to support and help train scientists in India who can then work to combat infectious diseases, such as malaria, where they are most prominent. The P. vivax sequencing was funded by NIAID as part of the NIAID funded Genomic Sequencing Center for Infectious Diseases at the Broad Institute under Contract No. HHSN272200900018C. The Burroughs Wellcome Fund was instrumental in providing pilot funds for the P. cynomolgi sequencing.

Researchers at the following institutions were also part of the P. vivax sequencing: The Broad Institute, the National Institute of Malaria Research in India, Arizona State University, and the Centers for Disease Control and Prevention.

Researchers at the following institutions were also part of the work on P. cynomolgi: Osaka University, Dokkyo Medical University, Japan’s Corporation for Production and Research of Laboratory Primates, Nagasaki University, Juntendo University’s School of Medicine, the University of Tokyo, the National Institute of Biomedical Innovation, the Centers for Disease Control and Prevention, and Arizona State University.

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Explainer: why mothers should breastfeed

Breast milk is one of the most important components of infant care. It provides complete nutrition and helps to prevent and fight infections. And it’s also safer – in much of the world, artificial infant feed is dangerous because clean water, which is essential for mixing with the powder, may not be available.

The World Health Organization (WHO) and UNICEFrecommend that infants be exclusively breastfed for six months and continue breastfeeding with the appropriate introduction of solids.

In Australia, although we have safe alternatives to breast milk and clean water to mix it with, we need to make mothers aware that breastfeeding needs to be the norm to protect their babies from infection. Babies are born with a relatively immature immune system that is supplemented with antibodies created by the mother in response to the environment that she and her baby share.

The risks of not breastfeeding include an increased incidenceof respiratory and gastrointestinal infections in infancy. What’s more, people who have not been breastfed have a higher incidence of obesity, diabetes, high blood pressure and coeliac and Crohn’s disease.

Mothers who breastfeed also enhance their own health –breastfeeding has been linked to a reduced incidence of breast and ovarian cancers, diabetes and cardiovascular disease. And, breastfeeding is environmentally-friendly – it doesn’t produce any additional waste from manufacturing or packaging.

Artificial infant feeds contain some components that are similar to breast milk but it’s impossible to mimic the vast array of live cells and other components of human milk that have important beneficial qualities. Nor can formula milk reflect or imitate the changing nature of breast milk over time. The amount and type of immune factors in breast milk change as babies grow and develop, and it even has a different composition if a baby is born prematurely. Indeed, an artificial infant feed that is largely the same as human milk simply doesn’t exist.

Breast milk introduces infants to flavours in foods that are thought to influence later eating habits. Research shows young children who have been breastfed eat a wider range of foods.

Mothers need accurate and appropriate information to help guide them through any difficulty they have with breastfeeding. Many groups advocate for breastfeeding and provide resources to educate the broader community. Information for families can be found on websites of the Australian Breastfeeding AssociationRaising Children Network and the Baby Friendly Hospital Initiative.

Some women begin breastfeeding when their babies are born but then stop soon afterwards for one reason or another, such as a lack of support, the need to return to work or the thought that they don’t have enough milk. Breast milk is difficult to measure and the focus on numbers in infant care with regular measures of weight gain probably doesn’t help these doubts.

It’s easy to measure volumes consumed when feeding artificially but monitoring the amount of breast milk an infant is getting is more reliant on indicators such as urine volume, stools, infant behaviour and growth. Most babies are able to grow and thrive on breast milk alone until they are six months old, with a neat system of supply and demand; the more frequently the baby feeds, the more milk the mother makes!

We need to support breastfeeding because it’s the optimal way to feed infants. We can do this by creating and maintaining ways to encourage mothers to breastfeed – but we also need to encourage them to continue breastfeeding until their child is two years of age or beyond.

Access to health-care professionals who are trained and committed to breastfeeding as well as increasing the community’s knowledge to support women who are doing so will be helpful. Breastfeeding should not be hidden away, young women who observe others successfully feeding will be more likely to choose to breastfeed themselves.

And having a strong culture of breastfeeding will mean there are lots of women around who have the wisdom of their own experience to share. Governments can help with legislation to protect and promote breastfeeding and by implementing theWHO and UNICEF global strategy for infant and young child feeding.

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Animal research provides a flawed model, so why not stop?

Much of the research involving the development of new drugs still uses animals. Apart from moral questions about inflicting pain and death on animals for the purpose of medical research, there are an increasing number of questions about the suitability of using laboratory animals for research into human diseases and drug testing.

There are many examples clearly showing that animal models are not predictive of human health. Recently, a group of scientists wrote an open letter in The Lancet (addressed to the UK prime minister and health secretary) pointing out that more than 90% of new drugs fail in clinical trials.

The authors of the letter say part of the reason for this is the reliance on animal testing to predict drug behaviour in people. They claim that animal tests do this with the same probability as the toss of a coin. And they suggest that animal research be replaced with promising new technologies that increase clinical predictability as well as improving efficiency and cost.

Other researchers have voiced similar concerns. An expert scientific group on phase one (screening for safety) clinical trials in the United Kingdom, for instance, concluded that pre-clinical animal studies may not reproduce the intended pharmacological effect, may give misleading results and, most significantly, may not reflect toxicity in humans.

 

 

Penicillin may not have seen the light of day of it had been tested in guinea pigs because it’s fatal to them. Linda Bartlett

 

 

While humans and other animals have biological and physiological similarities, differences at the molecular and cellular levels can result in different responses to drugs.

Animal testing gone wrong

The thalidomide tragedy of the late 1950s and early 1960s is a well-known example for the inappropriateness of animal research. Thalidomide had been tested on several animal species and found to be safe, even in large doses. Yet thousands of children worldwide were born with missing or shortened limbs after their mothers took the drug for morning sickness.

The website of Humane Research Australia lists over 60 drugs, including thalidomide, that have been “successfully” tested on animals, but are toxic to humans. The site notes that the list is not exhaustive.

In contrast, penicillin may not have seen the light of day if it had been tested on guinea pigs or rats – it kills guinea pigs and produces birth defects in rats. In fact, this antibiotic stayed on the shelf for over a decade because it was not effective in the rabbits on which it had been tested.

There are many other examples showing animal testing to have very poor predictive value for human diseases and toxicity. But animals are still used in laboratories all over the world to test the safety, toxicity and effectiveness of drugs. In fact, (and rather paradoxically) animal testing was made mandatory by drug regulators after the thalidomide tragedy. During the more than four decades since, it has become clear that animal tests fail to accurately predict human responses. And now, new testing methods are available.

In their book “Sacred cows and golden geese” Ray Greek and Jean Swingle Greek write that they could not find instances of advances that could be credited to the animal model despite searches of medical literature. Most drug advances are due to clinical observations by doctors and nurses on their human patients. But many clinical discoveries, discoveries by serendipity or other non-animal based discoveries were later “validated” in animals.

 

 

Most drug advances are due to clinical observations are later ‘validated’ in animals. Armin Kübelbeck

 

 

Emerging alternatives

Humane Research Australia provides a fact sheet with a range of alternatives to animal-based research. They include:

  • a greater focus on prevention;
  • epidemiology (the study of human populations);
  • autopsies;
  • in vitro research (using tissue and cell cultures); and
  • computer modelling.

Genomics (the study of the chromosomes of an organism), proteomics (study of proteins, particularly their structures and functions), nanotechnology, phage display (a method of quickly evaluating a huge range of potentially useful antibodies and then producing large quantities of the selected ones) and microfluidic chips (silicon microelectronics), are all new technology alternatives to animal testing that are worth considering.

Human organs on a chip, described as “cutting tiny grooves into silicon and plastic substrates, introducing living cells into the spaces, and hoping the end result will mimic a particular biological system, like a human organ”, are reportedly close to practical application.

The aim of this research is not to make replacement organs for transplant, but to replicate an organ’s functions to make the chips useful in testing substances for toxic and therapeutic effects. Organs on a chip have so far been developed for the humanlung and intestine. And this technology could help shorten the time it takes for new treatments to move to human testing and approval for general use.

 

 

A monkey photographed at an animal testing facility in the United States. SlimVirgin/Wikimedia Commons

 

 

Moving away from animal testing

Early this year, ABC’s 7.30 Report looked at a supercomputer in Melbourne.Professor Peter Taylor, the Director of the Victorian Life Science Computation Initiative at the University of Melbourne said, “One could imagine that if our ability to model how, say, drugs interact with their targets and how they affect an organism as a whole, then we could basically avoid any sort of animal testing. We could do it all in silica, if you like, in the computer, which would certainly be a great benefit. I don’t think there’s anybody who would quarrel with trying to do that.”

In the United States, the National Institutes of Health recently suspended all new grants for biomedical and behavioural research on chimpanzees after an expert committee concludedthat most such research was unnecessary. And the US National Research Council recommends animal-based tests be replaced as soon as possible with human cell-based assays, in silico (computer) models, and an increased emphasis on epidemiology.

At least one pharmaceutical company has already ceased its animal research program. Denmark-based Novo Nordiskstopped using animals for testing its products in November 2011.

New medicines should be safe and effective, but animal testing is a flawed model. Given that we now have a range of other established and promising methods, we should stop using animals in research and focus on alternatives.

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Artificial intelligence – can we keep it in the box?

We know how to deal with suspicious packages – as carefully as possible! These days, we let robots take the risk. But what if the robots are the risk? Some commentators argue we should be treating AI (artificial intelligence) as a suspicious package, because it might eventually blow up in our faces. Should we be worried?

Exploding intelligence?

Asked whether there will ever be computers as smart as people, the US mathematician and sci-fi author Vernor Vinge replied: “Yes, but only briefly”.

He meant that once computers get to this level, there’s nothing to prevent them getting a lot further very rapidly. Vinge christened this sudden explosion of intelligence the “technological singularity”, and thought that it was unlikely to be good news, from a human point of view.

Was Vinge right, and if so what should we do about it? Unlike typical suspicious parcels, after all, what the future of AI holds is up to us, at least to some extent. Are there things we can do now to make sure it’s not a bomb (or a good bomb rather than a bad bomb, perhaps)?

AI as a low achiever

Optimists sometimes take comfort from the fact the field of AI has very chequered past. Periods of exuberance and hype have been mixed with so-called “AI winters” – times of reduced funding and interest, after promised capabilities fail to materialise.

Some people point to this as evidence machines are never likely to reach human levels of intelligence, let alone to exceed them. Others point out that the same could have been said about heavier-than-air flight.

 

 

ra1000
Click to enlarge

 

 

The history of that technology, too, is littered with naysayers (some of whom refused to believe reports of the Wright brothers’ success, apparently). For human-level intelligence, as for heavier-than-air flight, naysayers need to confront the fact nature has managed the trick: think brains and birds, respectively.

A good naysaying argument needs a reason for thinking that human technology can never reach the bar in terms of AI.

Pessimism is much easier. For one thing, we know nature managed to put human-level intelligence in skull-sized boxes, and that some of those skull-sized boxes are making progress in figuring out how nature does it. This makes it hard to maintain that the bar is permanently out of reach of artificial intelligence – on the contrary, we seem to be improving our understanding of what it would take to get there.

Moore’s Law and narrow AI

On the technological side of the fence, we seem to be making progress towards the bar, both in hardware and in software terms. In the hardware arena, Moore’s law, which predicts that the amount of computing power we can fit on a chip doubles every two years, shows little sign of slowing down.

In the software arena, people debate the possibility of “strong AI” (artificial intelligence that matches or exceeds human intelligence) but the caravan of “narrow AI” (AI that’s limited to particular tasks) moves steadily forward. One by one, computers take over domains that were previously considered off-limits to anything but human intellect and intuition.

We now have machines that have trumped human performance in such domains as chess, trivia games, flying, driving, financial trading, face, speech and handwriting recognition – the list goes on.

Along with the continuing progress in hardware, these developments in narrow AI make it harder to defend the view that computers will never reach the level of the human brain. A steeply rising curve and a horizontal line seem destined to intersect!

What’s so bad about intelligent helpers?

Would it be a bad thing if computers were as smart as humans? The list of current successes in narrow AI might suggest pessimism is unwarranted. Aren’t these applications mostly useful, after all? A little damage to Grandmasters’ egos, perhaps, and a few glitches on financial markets, but it’s hard to see any sign of impending catastrophe on the list above.

That’s true, say the pessimists, but as far as our future is concerned, the narrow domains we yield to computers are not all created equal. Some areas are likely to have a much bigger impact than others. (Having robots drive our cars may completely rewire our economies in the next decade or so, for example).

The greatest concerns stem from the possibility that computers might take over domains that are critical to controlling the speed and direction of technological progress itself.

Software writing software?

What happens if computers reach and exceed human capacities to write computer programs? The first person to consider this possibility was the Cambridge-trained mathematician I J Good(who worked with Alan Turing code-breaking at Bletchley Park during the second world war, and later on early computers at the University of Manchester).

In 1965 Good observed that having intelligent machines develop even more intelligent machines would result in an “intelligence explosion”, which would leave the human levels of intelligence far behind. He called the creation of such machine “our last invention” – which is unlikely to be “Good” news, the pessimists add!

 

 

FlySi
Click to enlarge

 

 

In the above scenario, the moment computers become better programmers than humans marks the point in history where the speed of technological progress shifts from the speed of human thought and communication to the speed of silicon. This is a version of Vernor Vinge’s “technological singularity” – beyond this point, the curve is driven by new dynamics and the future becomes radically unpredictable, as Vinge had in mind.

Not just like us, but smarter!

It would be comforting to think that any intelligence that surpassed our own capabilities would be like us, in important respects – just a lot cleverer. But here, too, the pessimists see bad news: they point out that almost all the things we humans value (love, happiness, even survival) are important to us because we have particular evolutionary history – a history we share with higher animals, but not with computer programs, such as artificial intelligences.

By default, then, we seem to have no reason to think that intelligent machines would share our values. The good news is that we probably have no reason to think they would be hostile, as such: hostility, too, is an animal emotion.

 

 

JD Hancock
Click to enlarge

 

 

The bad news is that they might simply be indifferent to us – they might care about us as much as we care about the bugs on the windscreen.

People sometimes complain that corporations are psychopaths, if they are not sufficiently reined in by human control. The pessimistic prospect here is that artificial intelligence might be similar, except much much cleverer and much much faster.

Getting in the way

By now you see where this is going, according to this pessimistic view. The concern is that by creating computers that are as intelligent as humans (at least domains that matter to technological progress), we risk yielding control over the planet to intelligences that are simply indifferent to us, and to things that we consider valuable – things such as life and a sustainable environment.

If that sounds far-fetched, the pessimists say, just ask gorillas how it feels to compete for resources with the most intelligent species – the reason they are going extinct is not (on the whole) because humans are actively hostile towards them, but because we control the environment in ways that are detrimental to their continuing survival.

How much time do we have?

It’s hard to say how urgent the problem is, even if pessimists are right. We don’t yet know exactly what makes human thought different from current generation of machine learning algorithms, for one thing, so we don’t know the size of the gap between the fixed bar and the rising curve.

But some trends point towards the middle of the present century. In Whole Brain Emulation: A Roadmap, the Oxford philosophers Anders Sandberg and Nick Bostrom suggest our ability to scan and emulate human brains might be sufficient to replicate human performance in silicon around that time.

“The pessimists might be wrong!”

Of course – making predictions is difficult, as they say, especially about the future! But in ordinary life we take uncertainties very seriously, when a lot is at stake.

 

Sebastianlund
Click to enlarge

That’s why we use expensive robots to investigate suspicious packages, after all (even when we know that only a very tiny proportion of them will turn out to be bombs).

 

 

If the future of AI is “explosive” in the way described here, it could be the last bomb the human species ever encounters. A suspicious attitude would seem more than sensible, then, even if we had good reason to think the risks are very small.

At the moment, even that degree of reassurance seems out of our reach – we don’t know enough about the issues to estimate the risks with any high degree of confidence. (Feeling optimistic is not the same as having good reason to be optimistic, after all).

What to do?

A good first step, we think, would be to stop treating intelligent machines as the stuff of science fiction, and start thinking of them as a part of the reality that we or our descendants may actually confront, sooner or later.

Once we put such a future on the agenda we can begin some serious research about ways to ensure out-sourcing intelligence to machines would be safe and beneficial, from our point of view.

Perhaps the best cause for optimism is that, unlike ordinary ticking parcels, the future of AI is still being assembled, piece by piece, by hundreds of developers and scientists throughout the world.

The future isn’t yet fixed, and there may well be things we can do now to make it safer. But this is only a reason for optimism if we take the trouble to make it one, by investigating the issues and thinking hard about the safest strategies.

We owe it to our grandchildren – not to mention our ancestors, who worked so hard for so long to get us this far! – to make that effort.

Further information:
For a thorough and thoughtful analysis of this topic, we recommend The Singularity: A Philosophical Analysis by the Australian philosopher David Chalmers. Jaan Tallinn’s recent public lecture The Intelligence Stairway is available as a podcast or on YouTube via Sydney Ideas.

 

The Centre for the Study of Existential Risk
The authors are the co-founders, together with the eminent British astrophysicist, Lord Martin Rees, of a new project to establish a Centre for the Study of Existential Risk (CSER) at the University of Cambridge.

The Centre will support research to identify and mitigate catastrophic risk from developments in human technology, including AI – further details at CSER.ORG.

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Cell-infused ‘spray-on-skin’ helps leg ulcers heal more quickly

Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial

Prof Robert S Kirsner MD a, Prof William A Marston MD b, Prof Robert J Snyder DPM c, Tommy D Lee MSHS d, D Innes Cargill PhDd, Dr Herbert B Slade MD Corresponding AuthorEmail Address

Summary

Background

Many patients with venous leg ulcers do not heal with standard care. HP802-247 is a novel spray-applied cell therapy containing growth-arrested allogeneic neonatal keratinocytes and fibroblasts. We compared different cell concentrations and dosing frequencies of HP802-247 for benefit and harm when applied to chronic venous leg ulcers.

Methods

We enrolled adult outpatients from 28 centres in the USA and Canada with up to three ulcers, venous reflux confirmed by doppler ultrasonography, and adequate arterial flow in this phase 2, double-blind, randomised, placebo-controlled trial if at least one ulcer measured 2—12 cm2 in area and had persisted for 6—104 weeks. Patients were randomly assigned by computer-generated block randomisation in a 1:1:1:1:1 ratio to 5·0×106 cells per mL every 7 days or every 14 days, or 0·5×106 cells per mL every 7 days or every 14 days, or to vehicle alone every 7 days. All five groups received four-layer compression bandages. The trial sponsor, trial monitors, statisticians, investigators, centre personnel, and patients were masked to treatment allocation. The primary endpoint was mean percentage change in wound area at the end of 12 weeks. Analyses were by intention to treat, excluding one patient who died of unrelated causes before first treatment. This trial is registered with ClinicalTrials.gov NCT00852995.

Findings

45 patients were assigned to 5·0×106 cells per mL every 7 days, 44 to 5·0×106 cells per mL every 14 days, 43 to 0·5 ×106 cells per mL every 7 days, 46 to 0·5 ×106 cells per mL every 14 days, and 50 to vehicle alone. All required visits were completed by 205 patients. The primary outcome analysis showed significantly greater mean reduction in wound area associated with active treatment compared with vehicle (p=0·0446), with the dose of 0·5 ×106 cells/mL every 14 days showing the largest improvement compared with vehicle (15·98%, 95% CI 5·56—26·41, p=0·0028). Adverse events were much the same across all groups, with only new skin ulcers and cellulitis occurring in more than 5% of patients.

Interpretation

Venous leg ulcers can be healed with a spray formulation of allogeneic neonatal keratinocytes and fibroblasts without the need for tissue engineering, at an optimum dose of 0·5×106 cells per mL every 14 days.

Funding

Healthpoint Biotherapeutics.

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The Brain in Schizophrenia

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Borderline Personality Disorder

Borderline Personality Disorder (BPD) is one of the most controversial diagnoses in psychology today. Since it was first introduced in the DSM, psychologists and psychiatrists have been trying to give the somewhat amorphous concepts behind BPD a concrete form. Kernberg’s explication of what he calls Borderline Personality Organization is the most general, while Gunderson, though a psychoanalyst, is considered by many to have taken the most scientific approach to defining BPD. The Diagnostic Interview for Borderlines and the DIB-Revised were developed from research done by Gunderson, Kolb, and Zanarini. Finally, there is the “official” DSM-IV definition.

Some researchers, like Judith Herman, believe that BPD is a name given to a particular manifestation of post-traumatic stress disorder: in Trauma and Recovery, she theorizes that when PTSD takes a form that emphasizes heavily its elements of identity and relationship disturbance, it gets called BPD; when the somatic (body) elements are emphasized, it gets called hysteria, and when the dissociative/deformation of consciousness elements are the focus, it gets called DID/MPD. Others believe that the term “borderline personality” has been so misunderstood and misused that trying to refine it is pointless and suggest instead simply scrapping the term.

 

What causes Borderline Personality Disorder?

It would be remiss to discuss BPD without including a comment about Linehan’s work. In contrast to the symptom list approaches detailed below, Linehan has developed a comprehensive sociobiological theory which appears to be borne out by the successes found in controlled studies of her Dialectical Behavioral Therapy.

Linehan theorizes that borderlines are born with an innate biological tendency to react more intensely to lower levels of stress than others and to take longer to recover. They peak “higher” emotionally on less provocation and take longer coming down. In addition, they were raised in environments in which their beliefs about themselves and their environment were continually devalued and invalidated. These factors combine to create adults who are uncertain of the truth of their own feelings and who are confronted by three basic dialectics they have failed to master (and thus rush frantically from pole to pole of):

  • vulnerability vs invalidation
  • active passivity (tendency to be passive when confronted with a problem and actively seek a rescuer) vs apparent competence (appearing to be capable when in reality internally things are falling apart)
  • unremitting crises vs inhibited grief.

DBT tries to teach clients to balance these by giving them training in skills of mindfulness, interpersonal effectiveness, distress tolerance, and emotional regulation.

Kernberg’s Borderline Personality Organization

Diagnoses of BPO are based on three categories of criteria. The first, and most important, category, comprises two signs:

 

  • the absence of psychosis (i.e., the ability to perceive reality accurately)
  • impaired ego integration – a diffuse and internally contradictory concept of self. Kernberg is quoted as saying, “Borderlines can describe themselves for five hours without your getting a realistic picture of what they’re like.”

The second category is termed “nonspecific signs” and includes such things as low anxiety tolerance, poor impulse control, and an undeveloped or poor ability to enjoy work or hobbies in a meaningful way.

Kernberg believes that borderlines are distinguished from neurotics by the presence of “primitive defenses.” Chief among these is splitting, in which a person or thing is seen as all good or all bad. Note that something which is all good one day can be all bad the next, which is related to another symptom: borderlines have problems with object constancy in people — they read each action of people in their lives as if there were no prior context; they don’t have a sense of continuity and consistency about people and things in their lives. They have a hard time experiencing an absent loved one as a loving presence in their minds. They also have difficulty seeing all of the actions taken by a person over a period of time as part of an integrated whole, and tend instead to analyze individual actions in an attempt to divine their individual meanings. People are defined by how they lasted interacted with the borderline.

Other primitive defenses cited include magical thinking (beliefs that thoughts can cause events), omnipotence, projection of unpleasant characteristics in the self onto others and projective identification, a process where the borderline tries to elicit in others the feelings s/he is having. Kernberg also includes as signs of BPO chaotic, extreme relationships with others; an inability to retain the soothing memory of a loved one; transient psychotic episodes; denial; and emotional amnesia. About the last, Linehan says, “Borderline individuals are so completely in each mood, they have great difficulty conceptualizing, remembering what it’s like to be in another mood.”

Gunderson’s conception of BPD

Gunderson, a psychoanalyst, is respected by researchers in many diverse areas of psychology and psychiatry. His focus tends to be on the differential diagnosis of Borderline Personality Disorder, and Cauwels gives Gunderson’s criteria in order of their importance:

  • Intense unstable relationships in which the borderline always ends up getting hurt. Gunderson admits that this symptom is somewhat general, but considers it so central to BPD that he says he would hesitate to diagnose a patient as BPD without its presence.
  • Repetitive self-destructive behavior, often designed to prompt rescue.
  • Chronic fear of abandonment and panic when forced to be alone.
  • Distorted thoughts/perceptions, particularly in terms of relationships and interactions with others.
  • Hypersensitivity, meaning an unusual sensitivity to nonverbal communication. Gunderson notes that this can be confused with distortion if practitioners are not careful (somewhat similar to Herman’s statement that, while survivors of intense long-term trauma may have unrealistic notions of the power realities of the situation they were in, their notions are likely to be closer to reality than the therapist might think).
  • Impulsive behaviors that often embarrass the borderline later.
  • Poor social adaptation: in a way, borderlines tend not to know or understand the rules regarding performance in job and academic settings.

The Diagnostic Interview for Borderlines, Revised

Gunderson and his colleague, Jonathan Kolb, tried to make the diagnosis of BPD by constructing a clinical interview to assess borderline characteristics in patients. The DIB was revised in 1989 to sharpen its ability to differentiate between BPD and other personality disorders. It considers symptoms that fall under four main headings:

  1. Affect
    • chronic/major depression
    • helplessness
    • hopelessness
    • worthlessness
    • guilt
    • anger (including frequent expressions of anger)
    • anxiety
    • loneliness
    • boredom
    • emptiness
  2. Cognition
    • odd thinking
    • unusual perceptions
    • nondelusional paranoia
    • quasipsychosis
  3. Impulse action patterns
    • substance abuse/dependence
    • sexual deviance
    • manipulative suicide gestures
    • other impulsive behaviors
  4. Interpersonal relationships
    • intolerance of aloneness
    • abandonment, engulfment, annihilation fears
    • counterdependency
    • stormy relationships
    • manipulativeness
    • dependency
    • devaluation
    • masochism/sadism
    • demandingness
    • entitlement

The DIB-R is the most influential and best-known “test” for diagnosing BPD. Use of it has led researchers to identify four behavior patterns they consider peculiar to BPD: abandonment, engulfment, annihilation fears; demandingness and entitlement; treatment regressions; and ability to arouse inappropriately close or hostile treatment relationships.

 

DSM-IV criteria

The DSM-IV gives these nine criteria; a diagnosis requires that the subject present with at least five of these. In I Hate You — Don’t Leave Me!Jerold Kriesman and Hal Straus refer to BPD as “emotional hemophilia; [a borderline] lacks the clotting mechanism needed to moderate his spurts of feeling. Stimulate a passion, and the borderline emotionally bleeds to death.”

 

Traits involving emotions:

Quite frequently people with BPD have a very hard time controlling their emotions. They may feel ruled by them. One researcher (Marsha Linehan) said, “People with BPD are like people with third degree burns over 90% of their bodies. Lacking emotional skin, they feel agony at the slightest touch or movement.”

1. Shifts in mood lasting only a few hours.

2. Anger that is inappropriate, intense or uncontrollable.

 

Traits involving behavior:

3. Self-destructive acts, such as self-mutilation or suicidal threats and gestures that happen more than once

4. Two potentially self-damaging impulsive behaviors. These could include alcohol and other drug abuse, compulsive spending, gambling, eating disorders, shoplifting, reckless driving, compulsive sexual behavior.

 

Traits involving identity

5. Marked, persistent identity disturbance shown by uncertainty in at least two areas. These areas can include self-image, sexual orientation, career choice or other long-term goals, friendships, values. People with BPD may not feel like they know who they are, or what they think, or what their opinions are, or what religion they should be. Instead, they may try to be what they think other people want them to be. Someone with BPD said, “I have a hard time figuring out my personality. I tend to be whomever I’m with.”

6. Chronic feelings of emptiness or boredom. Someone with BPD said, “I remember describing the feeling of having a deep hole in my stomach. An emptiness that I didn’t know how to fill. My therapist told me that was from almost a “lack of a life”. The more things you get into your life, the more relationships you get involved in, all of that fills that hole. As a borderline, I had no life. There were times when I couldn’t stay in the same room with other people. It almost felt like what I think a panic attack would feel like.”

 

Traits involving relationships

7. Unstable, chaotic intense relationships characterized by splitting (see below).

8. Frantic efforts to avoid real or imagined abandonment

  • Splitting: the self and others are viewed as “all good” or “all bad.” Someone with BPD said, “One day I would think my doctor was the best and I loved her, but if she challenged me in any way I hated her. There was no middle ground as in like. In my world, people were either the best or the worst. I couldn’t understand the concept of middle ground.”
  • Alternating clinging and distancing behaviors (I Hate You, Don’t Leave Me). Sometimes you want to be close to someone. But when you get close it feels TOO close and you feel like you have to get some space. This happens often.
  • Great difficulty trusting people and themselves. Early trust may have been shattered by people who were close to you.
  • Sensitivity to criticism or rejection.
  • Feeling of “needing” someone else to survive
  • Heavy need for affection and reassurance
  • Some people with BPD may have an unusually high degree of interpersonal sensitivity, insight and empathy

9. Transient, stress-related paranoid ideation or severe dissociative symptoms

This means feeling “out of it,” or not being able to remember what you said or did. This mostly happens in times of severe stress.

 

Miscellaneous attributes of people with BPD:

  • People with BPD are often bright, witty, funny, life of the party.
  • They may have problems with object constancy. When a person leaves (even temporarily), they may have a problem recreating or remembering feelings of love that were present between themselves and the other. Often, BPD patients want to keep something belonging to the loved one around during separations.
  • They frequently have difficulty tolerating aloneness, even for short periods of time.
  • Their lives may be a chaotic landscape of job losses, interrupted educational pursuits, broken engagements, hospitalizations.
  • Many have a background of childhood physical, sexual, or emotional abuse or physical/emotional neglect.

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