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Myasthenia gravis

An autoimmune neuromuscular disorder that is characterized by fatigue and exhaustion of muscles. Abbreviated MG. MG is caused by a mistaken immune response to the body’s own nicotinic acetylcholine receptors, which are found in junctions between muscles and the nervous system. The body produces antibodies that attack these receptors, preventing signals from reaching the muscles. A number of treatments are available that help, including steroids and other immunosuppressive medications and anticholinergic medications.

Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. The name myasthenia gravis, which is Latin and Greek in origin, literally means “grave muscle weakness.” With current therapies, however, most cases of myasthenia gravis are not as “grave” as the name implies. In fact, for the majority of individuals with myasthenia gravis, life expectancy is not lessened by the disorder.

The hallmark of myasthenia gravis is muscle weakness that increases during periods of activity and improves after periods of rest. Certain muscles such as those that control eye and eyelid movement, facial expression, chewing, talking, and swallowing are often, but not always, involved in the disorder. The muscles that control breathing and neck and limb movements may also be affected.

What causes myasthenia gravis?

Myasthenia gravis is caused by a defect in the transmission of nerve impulses to muscles. It occurs when normal communication between the nerve and muscle is interrupted at the neuromuscular junction – the place where nerve cells connect with the muscles they control. Normally when impulses travel down the nerve, the nerve endings release a neurotransmitter substance called acetylcholine. Acetylcholine travels through the neuromuscular junction and binds to acetylcholine receptors which are activated and generate a muscle contraction.

In myasthenia gravis, antibodies block, alter, or destroy the receptors for acetylcholine at the neuromuscular junction which prevents the muscle contraction from occurring. These antibodies are produced by the body’s own immune system. Thus, myasthenia gravis is an autoimmune disease because the immune system – which normally protects the body from foreign organisms – mistakenly attacks itself.

What is the role of the thymus gland in myasthenia gravis?

 

The thymus gland, which lies in the upper chest area beneath the breastbone, plays an important role in the development of the immune system in early life. Its cells form a part of the body’s normal immune system. The gland is somewhat large in infants, grows gradually until puberty, and then gets smaller and is replaced by fat with age. In adults with myasthenia gravis, the thymus gland is abnormal. It contains certain clusters of immune cells indicative of lymphoid hyperplasia – a condition usually found only in the spleen and lymph nodes during an active immune response. Some individuals with myasthenia gravis develop thymomas or tumors of the thymus gland. Generally thymomas are benign, but they can become malignant.

The relationship between the thymus gland and myasthenia gravis is not yet fully understood. Scientists believe the thymus gland may give incorrect instructions to developing immune cells, ultimately resulting in autoimmunity and the production of the acetylcholine receptor antibodies, thereby setting the stage for the attack on neuromuscular transmission.

What are the symptoms of myasthenia gravis?

Although myasthenia gravis may affect any voluntary muscle, muscles that control eye and eyelid movement, facial expression, and swallowing are most frequently affected. The onset of the disorder may be sudden. Symptoms often are not immediately recognized as myasthenia gravis.

In most cases, the first noticeable symptom is weakness of the eye muscles. In others, difficulty in swallowing and slurred speech may be the first signs. The degree of muscle weakness involved in myasthenia gravis varies greatly among patients, ranging from a localized form, limited to eye muscles (ocular myasthenia), to a severe or generalized form in which many muscles – sometimes including those that control breathing – are affected. Symptoms, which vary in type and severity, may include a drooping of one or both eyelids (ptosis), blurred or double vision (diplopia) due to weakness of the muscles that control eye movements, unstable or waddling gait, weakness in arms, hands, fingers, legs, and neck, a change in facial expression, difficulty in swallowing and shortness of breath, and impaired speech (dysarthria).

Who gets myasthenia gravis?

Myasthenia gravis occurs in all ethnic groups and both genders. It most commonly affects young adult women (under 40) and older men (over 60), but it can occur at any age.

In neonatal myasthenia, the fetus may acquire immune proteins (antibodies) from a mother affected with myasthenia gravis. Generally, cases of neonatal myasthenia gravis are transient (temporary) and the child’s symptoms usually disappear within 2-3 months after birth. Other children develop myasthenia gravis indistinguishable from adults. Myasthenia gravis in juveniles is common.

Myasthenia gravis is not directly inherited nor is it contagious. Occasionally, the disease may occur in more than one member of the same family.

Rarely, children may show signs of congenital myasthenia or congenital myasthenic syndrome. These are not autoimmune disorders, but are caused by defective genes that produce proteins in the acetylcholine receptor or in acetylcholinesterase.

How is myasthenia gravis diagnosed?

Unfortunately, a delay in diagnosis of one or two years is not unusual in cases of myasthenia gravis. Because weakness is a common symptom of many other disorders, the diagnosis is often missed in people who experience mild weakness or in those individuals whose weakness is restricted to only a few muscles.

The first steps of diagnosing myasthenia gravis include a review of the individual’s medical history, and physical and neurological examinations. The signs a physician must look for are impairment of eye movements or muscle weakness without any changes in the individual’s ability to feel things. If the doctor suspects myasthenia gravis, several tests are available to confirm the diagnosis.

A special blood test can detect the presence of immune molecules or acetylcholine receptor antibodies. Most patients with myasthenia gravis have abnormally elevated levels of these antibodies. However, antibodies may not be detected in patients with only ocular forms of the disease.

Another test is called the edrophonium test. This approach requires the intravenous administration of edrophonium chloride or Tensilon(r), a drug that blocks the degradation (breakdown) of acetylcholine and temporarily increases the levels of acetylcholine at the neuromuscular junction. In people with myasthenia gravis involving the eye muscles, edrophonium chloride will briefly relieve weakness. Other methods to confirm the diagnosis include a version of nerve conduction study which tests for specific muscle “fatigue” by repetitive nerve stimulation. This test records weakening muscle responses when the nerves are repetitively stimulated. Repetitive stimulation of a nerve during a nerve conduction study may demonstrate decrements of the muscle action potential due to impaired nerve-to-muscle transmission.

A different test called single fiber electromyography (EMG), in which single muscle fibers are stimulated by electrical impulses, can also detect impaired nerve-to-muscle transmission. EMG measures the electrical potential of muscle cells. Muscle fibers in myasthenia gravis, as well as other neuromuscular disorders, do not respond as well to repeated electrical stimulation compared to muscles from normal individuals. Computed tomography (CT) may be used to identify an abnormal thymus gland or the presence of a thymoma.

A special examination called pulmonary function testing – which measures breathing strength – helps to predict whether respiration may fail and lead to a myasthenic crisis.

How is myasthenia gravis treated?

Today, myasthenia gravis can be controlled. There are several therapies available to help reduce and improve muscle weakness. Medications used to treat the disorder include anticholinesterase agents such asneostigmine and pyridostigmine, which help improve neuromuscular transmission and increase muscle strength. Immunosuppressive drugs such asprednisonecyclosporine, and azathioprinemay also be used. These medications improve muscle strength by suppressing the production of abnormal antibodies. They must be used with careful medical followup because they may cause major side effects.

Thymectomy, the surgical removal of the thymus gland (which often is abnormal in myasthenia gravis patients), reduces symptoms in more than 70 percent of patients without thymoma and may cure some individuals, possibly by re-balancing the immune system. Other therapies used to treat myasthenia gravis include plasmapheresis, a procedure in which abnormal antibodies are removed from the blood, and high-dose intravenous immune globulin, which temporarily modifies the immune system and provides the body with normal antibodies from donated blood. These therapies may be used to help individuals during especially difficult periods of weakness. A neurologist will determine which treatment option is best for each individual depending on the severity of the weakness, which muscles are affected, and the individual’s age and other associated medical problems.

What are myasthenic crises?

A myasthenic crisis occurs when the muscles that control breathing weaken to the point that ventilation is inadequate, creating a medical emergency and requiring a respirator for assisted ventilation. In patients whose respiratory muscles are weak, crises – which generally call for immediate medical attention – may be triggered by infection, fever, or an adverse reaction to medication.

What is the prognosis?

With treatment, the outlook for most patients with myasthenia gravis is bright: they will have significant improvement of their muscle weakness and they can expect to lead normal or nearly normal lives. Some cases of myasthenia gravis may go into remission temporarily and muscle weakness may disappear completely so that medications can be discontinued. Stable, long-lasting complete remissions are the goal of thymectomy. In a few cases, the severe weakness of myasthenia gravis may cause a crisis (respiratory failure), which requires immediate emergency medical care. (see above).

What research is being done?

Within the Federal Government, the National Institute of Neurological Disorders and Stroke (NINDS), one of the Federal Government’s National Institutes of Health (NIH), has primary responsibility for conducting and supporting research on myasthenia gravis.

Much has been learned about myasthenia gravis in recent years. Technological advances have led to more timely and accurate diagnosis, and new and enhanced therapies have improved management of the disorder. Much knowledge has been gained about the structure and function of the neuromuscular junction, the fundamental aspects of the thymus gland and of autoimmunity, and the disorder itself. Despite these advances, however, there is still much to learn. The ultimate goal of myasthenia gravis research is to increase scientific understanding of the disorder. Researchers are seeking to learn what causes the autoimmune response in myasthenia gravis, and to better define the relationship between the thymus gland and myasthenia gravis.

Today’s myasthenia gravis research includes a broad spectrum of studies conducted and supported by NINDS. NINDS scientists are evaluating new and improving current treatments for the disorder. One such study is testing the efficacy of intravenous immune globlin in patients with myasthenia gravis. The goal of the study is to determine whether this treatment safely improves muscle strength. Another study seeks further understanding of the molecular basis of synaptic transmission in the nervous system. The objective of this study is to expand current knowledge of the function of receptors and to apply this knowledge to the treatment of myasthenia gravis.

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NO GYM REQUIRED ;)

Everyone knows exercise plays an important role in our general health, but whether its a lack of motivation, the need to travel to the gym, the cost of equipment, or simply know-how, these supposed obstacles often stand in our way. In reality, all you need is yourself. Here’s how you can get a full-body workout with nothing but your body.

Note: To be clear, some of the exercises we’ll be discussing in this post will require more than just you. For example, you might need to borrow a table in your home or place your feet underneath the couch. While most of the exercises won’t require any external objects, the ones that do will be things you’ll have access to virtually anywhere. Technically this means you’ll need more than just your body, but seeing as everything requires gravity and a ground to walk on we believe that utilizing the occasional piece of furniture is a fair caveat.

The Four Core Rules

Before we jump in to the four different types of exercise—cardio, upper body, core, and lower body—and their explanations, here are a few very important rules to remember:

  1. Always remember to breathe. This seems obvious, but when you’re in the middle of an exercise you may actually forget. In most cases you’ll exhale when you do the hard work (e.g. the pushing up part of a push up), and inhale on the easier part (e.g. when you lower your body for the push up). This isn’t always the case, however, and special breathing instructions are noted where relevant in this post.
  2. Form is extremely important. If you do an exercise wrong, what seems like progress initially will quickly dissipate and possibly result in injury. Be sure you’re doing the exercises correctly before you begin. Ask a friend to watch your form first. If you know a professional, ask them to help guide you. While this guide will explain proper form, it is your responsibility to ensure you doing the exercises properly and not cutting any corners.
  3. Take it slowly. While aerobic exercise if often the exception, most other exercise is best performed slowly. This doesn’t mean you should take long breaks in between each push up and sit up, but that you shouldn’t perform each as quickly as possible. Going slowly will work the muscle more and make you stronger.
  4. Your goal is to fail. The key to a good work out is failure. That doesn’t mean giving up because you’re frustrated and tired, but rather pushing the limits of your strength until your strength is spent. Obviously you don’t want to push yourself to the point of injury, but that shouldn’t be a concern so long as you’re exhibiting the proper form. Don’t worry too much about the number of repetitions of any given exercise, but instead concentrate on working as hard as you can. A larger number of push ups doesn’t necessarily mean you’re stronger. Some days you’ll have more energy than others and will perform better. Some days you’ll perform worse. The key is to do the best you can with all of the energy you have. If you fail, you succeed.

Now that you’re ready to get started, we recommend utilizing all the information below but if you want to skip around here’s a table of contents:

Cardio

Aerobic/cardiovascular exercise, or cardio for short, targets your heart. In addition to improving your heart health, it also provides benefits to many other areas in your body as you’ll need to work multiple muscle groups in order to perform aerobic exercise. While the good news is that cardio can be great for your entire body, the bad news is that most people hate doing it because they hate running. It doesn’t have to be terrible, however, as there are a couple of variations that might make it easier and more fun for you. Here are two options that can make running easier and more fun, plus they only take about 20-30 minutes 2-3 times per week.

Interval TraininG

Some find running unappealing because it exhausts your entire body and you have to keep doing it for quite some time. This is because most people train for endurance, but that’s not necessary. Interval training is an excellent alternative that essentially involves working much harder for a shorter period of time. (Interval training applies to more than just running, of course, but that’s another topic for another time.)

There are several methods of running in intervals, but here’s one example to give you an idea:

  • A light jog for a few minutes to get moving (2-5 minutes).
  • 1 minute of high-speed running, then 1 minute of low-speed jogging, repeated 5-10 times (depending on your stamina).
  • A 5 minute light jog to cool down (or more if necessary).

While you’re technically running about as fast as you can for that one minute, you only have to maintain that intensity for a very short period of time. You immediately get a break afterwards. Instead of enduring 30-60 minutes of sustained running, you only have to endure short bursts. For some, this is preferable.

Each burst can vary in timing as well. For example, some structure their intervals like a pyramid, so you start small, peak in the middle of the intervals, and then slow back down towards the end. My personal method of choice is Swedish Fartlek (speed play) training, as it provides variation in the types of running performed in a single session. For some, interval training may sound like complete hell, but if you’ve never been able to stick to long distance running you may find it easier to accomplish and the results more quickly rewarding.

Stair Climbing

Stair climbing is a simple exercise you can perform anywhere there is a staircase, whether that staircase is in your home or in public. You’ve likely seen films depict athletes running up large staircases in stadiums before, and this is because it’s great exercise. It’s especially effective if you skip every other step. How can you do this as a practical exercise? If you have access to a standard staircase at home, just follow these steps:

  1. Run up and down the staircase as many times as you can. Skip steps in-between if you can. Stop when you are so tired you cannot continue anymore. When you get to this point, you mostly likely will only be part of the way up the staircase. If you made it to the top, chances are you’ve got another climb left in you.
  2. Take the total number of times you made it to the the top of the stairs and cut it in half. For example, let’s say you maxed out at 20 times and that halved number is 10.
  3. The next time you climb stairs, run up and down 10 times each (the halved number).
  4. Take a 60-90 second break, then do another set of 10 (the halved number).
  5. Take another 60-90 second break, then do at least 10 (the halved number). If you can do more, do more. Your goal is to push yourself until you’re too tired to go on.
  6. As this gets easier, increase the number of times you climb the stairs per set so you’re always pushing yourself to work harder.

Not everyone has a staircase, however, so this exercise isn’t always an option at home. If you don’t want to go out and use a public staircase with regularity, just add stair climbing to part of your everyday life. When you have the option to take the stairs, take them, and run up them skipping every other step. This is a good way to work in a little exercise to your regular day.

Note: Stair climbing is also great for strengthening the muscles in your legs, so if they are part of your routine you may choose to skip stair steps in the lower body section.

Upper Body

When we’re talking about upper body exercise, we’re primarily talking about working the muscles in your shoulders, arms, and chest. These exercises are some of the easiest to do and the most rewarding because you tend to see results quickly. That said, upper body exercises are some of the easiest to perform incorrectly and that can 1) cause you to hurt yourself, and 2) fool yourself into believing you’re making progress when you’re essentially doing nothing at all. While this is the case with any exercise, it’s very important that you take the time to learn the proper form or you will be wasting your time.

With every upper body exercise you also need to figure out how many times to do each. Obviously you won’t get very far if you do just a single push up and call it a day, but how do you know how many push ups to do, when to take a break, and so on? Here is a method to figure that out, using push ups as an example (but you can use this same method for any of the exercises in the upper body section):

  • Do as many push ups as you can without taking a break. Don’t stop because you’re tired—stop because you cannot physically do another push up.
  • Take the total number of push ups you were able to do and cut that down to half. For example, if you did 30 push ups total that would result in the number 15.
  • Next time you do your push ups, do three sets of that number (15 in our example) with 60-90 seconds breaks in between. If you can manage to do more on the last set, you should.

As you get stronger you’ll need to increase the number of push ups you do in each set. If you ever notice things are getting too easy for you, just add 2-5 push ups to each set to make things more challenging.

Push Ups

Push ups are a wonderfully effective exercise that work several muscles, including the pectorals, deltoids, and triceps—essentially meaning the muscles in your chest, on the rounded part of your shoulder, and on the backside of your upper arms. While it may seem like a simple exercise to do, good form is vital. One of our favorite push up plans isOne Hundred Push Ups, which explains how to perform the exercise properly:

Lie prone on the ground with hands placed as wide or slightly wider than shoulder width. Keeping the body straight, lower body to the ground by bending arms at the elbows. Raise body up off the ground by extending the arms. Repeat. Body weight should be lifted by the arms; don’t be tempted to use your butt, stomach or the lower half of your body to pull yourself up. To maintain correct body alignment, imagine a straight line running from your head down to your ankles.

The One Hundred Push Ups plan is a very good way to build up your strength quickly, but if you’re not quite ready to take on a large goal just use the method described earlier to figure out the right number of push ups per set that works best for you.

Dips

Dips are a great upper body-strengthening exercise you can do with the aid of a chair or a bench. While they’ll strengthen many of the same muscles as push ups, they’ll do a bit more to work the rhomboid muscles in your back. The 150 Dips program explains the proper form:

Stand with your back to a chair or bench. Be sure that the object is sturdy and can comfortably support your body weight. Bend your legs and place your palms on the front edge of the bench, with your fingers pointing forward. Slowly walk your feet out in front of you, until the majority of your body weight is resting on your arms. Inhale, and keeping your elbows tucked in at your sides, slowly bend your arms and lower your body until your upper arms are parallel with the floor (see pic below). You should also notice your hips have dropped straight down toward the floor. Hold for a second, then exhale and straighten your arms back up to the starting position.

The 150 Dips is one good way to quickly build up strength, but if you want to start smaller just follow the method described at the beginning of this section to figure out the right number of dips for you.

Curls

Working your biceps—the double-headed muscle on the inside of your upper arm—is the part of the arm most people like to build up and show off. It’s also pretty much impossible to build up without lifting some kind of weight and so, in this particular case, your body isn’t sufficient to get the job done on its own. If building your biceps is important to you, the best thing you can do to keep the workout at home is go buy some dumbbells at various weights and use them to do curls (which we’ll discuss in a minute). A good starting weight will depend on your size and current muscle mass, so be sure to ask for help when purchasing any dumbbells so you don’t buy any that are too heavy. You’re always better off starting lighter and working your way up or you could wind up with an injury.

If you don’t want to purchase anything and just use something you have around the house, anything with a handle and even weight can make a decent substitute. One option is a backpack, so long as you distribute the weight evenly and can keep it from shifting within the bag. Another option is a gallon of milk or juice, or some other kind of container with a handle that can be filled with liquid.

Once you’ve got your weight you can start doing your curls. If you have two even weights, you can perform curls with both arms at the same time. If not, one arm at a time is okay. To start, extend your arm down by your side and hold the weight, palms facing forward. Make sure your elbows are tucked and your shoulders are straight. When you’re in position, slowly bring the weight up to your shoulders—not outside of your shoulders and not too far into your chest. Doing this correctly will feel like you’re squeezing your biceps. While some exercises do not require a full range of motion, when you’re doing curls it is vital that you go all the way up and all the way back down each time. Completely the full range of motion and complete it slowly. If you rush you can hurt yourself.

Three sets of 12 repetitions is a good place to start when you begin with curls, while attempting to do more on your final set if possible. If you cannot handle this many, the weight you are using is too heavy and you should start with something lighter. Don’t feel discouraged if you’re starting with light weights or are unable to complete all three sets the first time. You’ll find that in the beginning you’ll be able to increase the amount of weight you’re using about every 2-3 weeks. Eventually that will slow down, but it’s very encouraging in the beginning. Start slow and light and you’ll be rewarded for it.

Core / Midsection

To exercise your core you’ll be doing sit ups—but not just any sit ups! While the standard vrunchisn’t necessarily a bad exercise, multiple variations on the sit up can be much more effective at working your entire core. Some of these effective variations come from Pilates exercise regimens. Chances are you’ve heard of Pilates or even tried it, but avoided it because of the expense and/or equipment. Fortunately there are plenty of sit up-like exercises you can borrow from Pilates that require nothing more than your body (and preferably an exercise mat or towel for comfort). Let’s take a look at a couple of those and some others that are helpful as well.

The Roll Up

The roll up is very similar to a normal sit up with a few key differences. First, you start with you arms all the way back behind you and you bring them all the way forward into a sitting position. Breathing is key during the process as you inhale as you begin to move upward and exhale as you complete. You also perform this motion slowly, as rushing through the process will do far less to work your core. Learning to do the roll up properly can take a little practice, and you may not be able to do it fully at first if you’re just getting started. Watch the video to the left for a demonstration of the easy and the hard way to do this exercise.

The (Half) Roll Down

The roll down will feel a lot like a reverse sit up, and therefore may seem redundant, but it’s an important exercise to pair with the roll up. Start sitting up with your feet flat on the floor creating a 45 degree angle. Just to get in the right position, place your hands under your thighs and hold yourself sitting up. You can leave your hands there as you do this exercise, however for a greater challenge you want to place your hands extended out in front of you. From this starting position, inhale, then exhale as you lean back slowly towards the ground. You’ll be extending down until your shoulder blades are just lightly touching the surface below you. It’s important that you do not go down so far that you’re being supported by the ground but just far enough that you know you’ve completed the first full range of motion. Now inhale, then exhale as you move back up into the starting position. Once you’re there, your back will be slightly curved. Lift your head up and adjust your back into a straight spine position. Feel free to do multiple sets of this exercise, but never more than 15 repetitions per set.

The Hundred

The hundred is complicated, tiring, and best explained visually (so watch the video to your left). To perform this exercise, you lay flat on your back and lift up your knees until they create an approximately 45 degree angle with your feet still touching the ground. Start by keeping your arms down with your palms flat against the ground. Don’t press your back flat on the floor or arch it up—try to keep it as centered as possible. Once you’re in the correct position, lower your chin slightly and begin to lift yourself upwards by pulling your abdomen in. As you do, lift your hands off the ground and keep your arms extended straight. Some versions of the hundred suggest that you lift your feet off the ground so the bend in your legs create a 90 degree angle. If this is too hard for you, other versions suggest you can perform this exercise without lifting your feet. All that work you just did was to get you in the proper position. Now you get to do the hard part.

While keeping your arms flat and extended, move them up and down rapidly. Each up and down motion counts as one repetition. Every five repetitions you’ll alternate between inhaling and exhaling. For example, you’ll inhale on the first repetition, the 10th, the 20th, etc. You’ll also exhale on the fifth, 15th, 25th, and so on. When you reach 100, you’re done. If you become tired while performing this exercise, take a short rest at the 50th repetition and start right back up again. As you may have noted from the complexity of this description, there’s a bit of a learning curve and practice involved with the hundred. Be sure to watch the video so you can see how it’s done and practice a few times on your own before you attempt the full set. Once you get used to it you should find it easy to perform regularly.

The Basic Plank

The basic plank is a simple but challenging exercise that targets the whole of your core. It might take a little practice to get right at first, but once you get it down you just have to hold yourself in the proper position.WebMD explains how it’s done:

Lie on your stomach, elbows close to your sides and directly under your shoulders, palms down. Engage the abs and slowly lift your torso off the floor, maintaining a stiff torso and legs. Avoid sagging at the low back or hiking up your hips. Continue to breathe while holding this position for 15 seconds or more.

Your starting goal should be to perform 3 sets of 6-12 repetitions of this exercise, but you’ll want to increase the number of repetitions as you’re able to do so.

Other Core Exercises

There are tons of ways you can strengthen your core, and these are just a few that will help you do the job. For more options, this PDF provides visual demonstrations of many, many abdominal exercises that don’t require any equipment. Additionally, as silly as it may seem at first, this two towels ab workout is actually an effective option and is basically the poor man’s version of the ab roller.

Lower Body

With cardio, core, and upper body exercise underway it can sometimes seem a little excessive to work your lower body. In many ways, you will be working muscles that other exercises have already targeted. That said, you’ll be neglecting multiple areas if you don’t bother with your lower body specifically. Here are a couple of exercises you’ll want to do to make sure you’re not leaving anything out.

Squats

Squats are a great, simple exercise to strengthen all sorts of good stuff including your legs, lower back, hips, buttocks, and even bones. So long as they’re performed correctly, they’re an excellent way to target the majority of the muscles in your lower body. So how do you squat correctly? The folks who created the 200 Squats program can explain:

Stand up straight with your feet firmly planted on the ground approximately shoulder width apart. To help maintain a straight back as you perform the exercise, it’s a good idea to focus on an object directly ahead of you at eye level.

2. Contract your abdominal muscles as you bend your legs at the knees. Either stretch your arms out ahead of you, lightly position your hands behind your ears or hold your arms at your side as you slowly lower yourself into a squatting position. Lower your body to a position where your thighs are almost parallel to the floor. Return to the starting position and repeat.

Much like push ups, a squat is a comprehensive exercise that you can do pretty much anywhere. This makes it easy to fit in a set whenever you have some spare time. If you want to make it to 200, the 200 Squats program is a good way to get there. If you’re looking for something a little less daunting, simply try three sets of 20 squats to start, performing additional squats during the last set if you can manage. Continue to work your way up whenever the exercise gets to be easy. Remember, you won’t build additional strength if you don’t continue to push yourself as you improve.

Stair Steps / Step Ups

Much like climbing stairs, you can build a lot of lower body strength by performing single stair steps. The key here, however, is not to step up a lower stair like you’d find on a staircase but a higher one that’s a little lower than the height of your knee. If you try to step up and your knee comes up higher than your hip, the step is too high and you’ll need to find something lower. If you were in a gym you could use a standard bench press bench, but at home a wide stool, flat ottoman, or other furniture of similar height should do just fine. A park bench works well, too. Just be sure it supports your weight before you start stepping. If it breaks underneath you, you’re obviously going to hurt yourself.

To perform the stair step exercise, you’ll want to do one leg at a time. Starting with the left, place your left foot on the bench or stool. Using the strength from that left leg, push yourself upward to bring your right foot onto the stool as well. Do not use the strength from your right leg to help you. You will need it later when you switch and your right foot is on the stool. Perform this action 10-12 times. When you’ve finished with one leg, switch to the other and perform 10-12 repetitions as well. This constitutes one set. Take a 60-90 second break after each set and perform a total of three.

As these stair steps become easier, you do not necessarily want to increase you repetitions as you might with other exercises. Instead, you may consider adding weight to your legs or your arms. Adding weight to your legs generally means purchasing a specific kind that you can attach for the purpose. Adding weight to your arms, however, just involves holding something. Ideally you would hold dumbbells of equal weight in each arm, starting at 5 lbs. each and working your way up as you grow stronger. If you don’t have dumbbells available, gallons of liquid—such as milk—can make a good substitute. Just be sure the weight is equal in both arms or you can cause balance issues and potentially hurt yourself.

Regardless of whether you’re using weights or not, be sure to perform the stair steps slowly and avoid putting strain on your knees. You can easily cause injury by moving too fast and putting unwanted pressure where it doesn’t belong.

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The 29 Healthiest Foods on the Planet

FRUITS

01. Apricots
The Power:  Beta-carotene, which helps prevent free-radical damage and protect the eyes. The body also turns beta-carotene into vitamin A, which may help ward off some cancers, especially of the skin. One apricot has 17 calories, 0 fat, 1 gram of fiber. Snacks on them dried, or if you prefer fresh, buy when still firm; once they soften, they lose nutrients.

02. Avocados
The Power:  Oleic acid, an unsaturated fat that helps lower overall cholesterol and raise levels of HDL, plus a good dose of fiber. One slice has 81 calories, 8 grams of fat and 3 grams of fiber. Try a few slices instead of mayonnaise to dress up your next burger.

03. Raspberries
The Power:  Ellagic acid, which helps stall cancer-cell growth. These berries are also packed with vitamin C and are high in fiber, which helps prevent high cholesterol and heart disease. A cup has only 60 calories, 1 gram of fat and 8 grams of fiber. Top plain low-fat yogurt or oatmeal (another high fiber food) with fresh berries.

05. Cantaloupe
The Power:  Vitamin C (117mg in half a melon, almost twice the recommended daily dose) and beta-carotene – both powerful antioxidants that help protect cells from free-radical damage. Plus, half a melon has 853mg of potassium – almost twice as much as a banana, which helps lower blood pressure. Half a melon has 97 calories, 1 gram of fat and 2 grams of fiber. Cut into cubes and freeze, then blend into an icy smoothie.

06. Cranberry Juice
The Power:  Helps fight bladder infections by preventing harmful bacteria from growing. A cup has 144 calories, 0 grams of fat and 0 fiber. Buy 100 percent juice concentrate and use it to spice up your daily H20 without adding sugar.

07. Tomato
The Power:  Lycopene, one of the strongest carotenoids, acts as an antioxidant. Research shows that tomatoes may cut the risk of bladder, stomach and colon cancers in half if eaten daily. A tomato has 26 calories, 0 fat and 1 gram of fiber. Drizzle fresh slices with olive oil, because lycopene is best absorbed when eaten with a little fat.

08. Raisins
The Power:  These little gems are a great source of iron, which helps the blood transport oxygen and which many women are short on. A half-cup has 218 calories, 0 fat and 3 grams of fiber. Sprinkle raisins on your morning oatmeal or bran cereal – women, consider this especially during your period.

09. Figs
The Power:  A good source of potassium and fiber, figs also contain vitamin B6, which is responsible for producing mood-boosting serotonin, lowering cholesterol and preventing water retention. The Pill depletes B6, so if you use this method of birth control, make sure to get extra B6 in your diet. One fig has 37 to 48 calories, 0 fat and 2 grams of fiber. (Cookie lovers – fig bars have around 56 calories, 1 gram of fat and 1 gram of fiber per cookie). Fresh figs are delicious simmered alongside a pork tenderloin and the dried variety make a great portable gym snack.

10. Lemons and Limes
The Power:  Limonene, furocoumarins and vitamin C, all of which help prevent cancer. A wedge has 2 calories, 0 fat and 0 fiber. Buy a few of each and squeeze over salads, fish, beans and vegetables for fat free flavor. See also: Beneficial Bytes: Lemons and Limes.

VEGETABLES

11. Onions
The Power:  Quercetin is one of the most powerful flavonoids (natural plant antioxidants). Studies show it helps protect against cancer. A cup (chopped) has 61 calories, 0 fat and 3 grams of fiber. Chop onions for the maximum phytonutrient boost, or if you hate to cry, roast them with a little olive oil and serve with rice or other vegetables.

12. Artichokes
The Power:  These odd-looking vegetables contain silymarin, an antioxidant that helps prevent skin cancer, plus fiber to help control cholesterol. One medium artichoke has 60 calories, 0 fat and 7 grams of fiber. Steam over boiling water for 30 to 40 minutes. Squeeze lemon juice on top, then pluck the leaves off with your fingers and use your teeth to scrape off the rich-tasting skin. When you get to the heart, you have found the best part!

13. Ginger
The Power:  Gingerols may help reduce queasiness; other compounds may help ward off migraines and arthritis pain by blocking inflammation-causing prostaglandins. A teaspoon of fresh gingerroot has only 1 calorie, 0 fat and 0 fiber. Peel the tough brown skin and slice or grate into a stir-fry.

14. Broccoli
The Power:  Indole-3-carbinol and sulforaphane, which help protect against breast cancer. Broccoli also has lots of vitamin C and beta-carotene. One cup (chopped) has 25 calories, 0 fat and 3 grams of fiber. Don’t overcook broccoli – instead, microwave or steam lightly to preserve phytonutrients. Squeeze fresh lemon on top for a zesty and taste, added nutrients and some vitamin C.

15. Spinach
The Power:  Lutein and zeaxanthin, carotenoids that help fend off macular degeneration, a major cause of blindness in older people. Plus, studies show this green fountain of youth may help reverse some signs of aging. One cup has 7 calories, 0 fat and 1 gram of fiber. Add raw leaves to a salad or saute with a little olive oil and garlic.

16. Bok Choy (Chinese cabbage)
The Power:  Brassinin, which some research suggests may help prevent breast tumors, plus indoles and isothiocyanates, which lower levels of estrogen, make this vegetable a double-barreled weapon against breast cancer. A cup will also give you 158mg of calcium (16 percent of your daily recommended requirement) to help beat osteoporosis. A cup (cooked) has 20 calories, 0 fat and 3 grams of fiber. Find it in your grocer’s produce section or an Asian market. Slice the greens and juicy white stalks, then saute like spinach or toss into a stir-fry just before serving.

17. Squash (Butternut, Pumpkin, Acorn)
The Power:  Winter squash has huge amounts of vitamin C and beta-carotene, which may help protect against endometrial cancer. One cup (cooked) has 80 calories, 1 gram of fat and 6 grams of fiber. Cut on in half, scoop out the seeds and bake or microwave until soft, then dust with cinnamon.

18. Watercress and Arugula
The Power:  Phenethyl isothiocyanate, which, along with beta-carotene and vitamins C and E, may help keep cancer cells at bay. One cup has around 4 calories, 0 fat and 1 gram of fiber. Do not cook these leafy greens; instead, use them to garnish a sandwich or add a pungent, peppery taste to salad.

19. Garlic
The Power:  The sulfur compounds that give garlic its pungent flavor can also lower LDL (“bad”)cholesterol, lower blood pressure and even reduce your risk of stomach and colon cancer. A clove has 4 calories, 0 fat and 0 fiber. Bake a whole head for 15 to 20 minutes, until soft and sweet and spread on bread instead of butter.

GRAINS, BEANS, DAIRY AND NUTS

20. Quinoa
The Power:  A half cup of cooked quinoa has 5 grams of protein, more than any other grain, plus iron, riboflavin and magnesium. A half-cup has 318 calories, 5 grams of fat and 5 grams of fiber. Add to soup for a protein boost. Rinse first, or it will taste bitter.

21. Wheat Germ
The Power:  A tablespoon gives you about 7 percent of your daily magnesium, which helps prevent muscle cramps; it is also a good source of vitamin E. One tablespoon has 27 calories, 1 gram of fat and 1 gram of fiber. Sprinkle some over yogurt, fruit or cereal.

22. Lentils
The Power:  Isoflavones, which may inhibit estrogen-promoted breast cancers, plus fiber for heart health and an impressive 9 grams of protein per half cup. A half-cup (cooked) has 115 calories, 0 fat and 8 grams of fiber. Isoflavones hold up through processing, so buy lentils canned, dried or already in soup. Take them to work, and you will have a protein packed lunch.

23. Peanuts
The Power:  Studies show that peanuts or other nuts (which contain mostly unsaturated “good” fat) can lower your heart-disease risk by over 20 percent. One ounce has 166 calories, 14 grams of fat and 2 grams of fiber. Keep a packet in your briefcase, gym bag or purse for a protein-packed post-workout nosh or an afternoon pick me up that will satisfy you until supper, or chop a few into a stir-fry for a Thai accent. See also: The Nut Case

24. Pinto Beans
The Power:  A half cup has more than 25 percent of your daily requirement of folate, which helps protect against heart disease and reduces the risk of birth defects. A half-cup (canned) has 103 calories, 1 gram of fat and 6 grams of fiber. Drain a can, rinse and toss into a pot of vegetarian chili.

25. Yogurt
The Power:  Bacteria in active-culture yogurt helps prevent yeast infections; calcium strengthens bones. A cup has 155 calories, 4 grams of fat, 0 grams of fiber. Get the plain kind and mix in your own fruit to keep calories and sugar down. If you are lactose intolerant, never fear — yogurt should not bother your tummy.

26. Skim Milk
The Power:  Riboflavin (a.k.a. vitamin B2) is important for good vision and along with vitamin A might help improve eczema and allergies. Plus, you get calcium and vitamin D, too. One cup has 86 calories, 0 fat and 0 fiber. If you are used to high fat milk, don’t go cold turkey; instead, mix the two together at first. Trust this fact: In a week or two you won’t miss it!

SEAFOOD

27. Shellfish (Clams, Mussels)
The Power:  Vitamin B12 to support nerve and brain function, plus iron and hard-to-get minerals like magnesium and potassium. Three ounces has 126 to 146 calories, 2 to 4 grams of fat and 0 fiber. Try a bowl of tomato-based (and low fat) Manhattan clam chowder.

28. Salmon
The Power:  Cold-water fish like salmon, mackerel and tuna are the best sources of omega-3 fatty acids, which help reduce the risk of cardiac disease. A 3-ounce portion (cooked) has 127 calories, 4 grams of fat, 0 fiber. Brush fillets with ginger-soy marinade and grill or broil until fish flakes easily with a fork.

29. Crab
The Power:  A great source of vitamin B12 and immunity-boosting zinc. A 3-ounce portion has 84 calories, 1 gram of fat, 0 fiber. The “crab” in sushi is usually made from fish; buy it canned instead and make your own crab cakes.

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Cut your number of migraines in half

Nearly 40 percent of people who have migraines could benefit from taking a daily medication to help prevent them, studies show. Yet only a small percentage of migraine patients take preventive therapy.

Most rely on painkillers that treat the migraines once they hit (called acute treatment), but this approach doesn’t always provide relief from the debilitating pain and nausea of migraines.

The American Academy of Neurology and the American Headache Society want to change that. Together, they published new guidelines in the journal Neurology, recommending a number of effective preventive therapies, including prescriptions, over-the-counter drugs and natural remedies.

 

“If your migraines are severe, there’s hope for you, and the medicines work.”

– Dr. Stephen D. Silberstein of the Jefferson Headache Center at Thomas Jefferson University in Philadelphia

 

After reviewing hundreds of studies, they found that a variety of therapies can reduce the number of migraine attacks by more than half.

The message: “If your migraines are severe, there’s hope for you, and the medicines work,” said Dr. Stephen D. Silberstein of the Jefferson Headache Center at Thomas Jefferson University in Philadelphia.

Those who are candidates for preventive therapy fall into one of four categories:

1. They average more than one migraine attack per week;

2. Their medications to treat the migraines don’t work well;

3. They take these medications so often that they get rebound headaches;

4. The migraine is accompanied by serious severe symptoms like seizures.

For those who have tried a preventive therapy and gave up on it, consider these points: Your dose may have been too high (causing side effects), too low (making it ineffective), or you may need a different treatment. Not all drugs are effective for all people, so it may take some trial and error with different doses and different medications before finding one that works for you. Some headache experts combine two preventive therapies, starting with one, and then adding another on top of it for greater reduction in headaches.

It’s important to work with a doctor who treats headaches and can guide you to a treatment that works. Some of these medications treat other problems or have known side effects, such as lowering blood pressure, weight loss or weight gain, so a doctor needs to treat you as a “whole” person, considering your overall health when deciding on a medication.

The treatments mentioned below fall into two categories, both considered effective. Level A medications have established effectiveness and Level B have probable effectiveness.

“The difference between Level A and B has to do with how much a drug has been studied, not how effective the drug is,” Silberman said.

Anti-seizure dugs: Divalproex sodium or sodium valproate (Depakote, Depacon, etc) and topiramate (Topamax).

Beta-blockers: Metroprolol (Lopressor), propranolol (Inderal), timolol (Blocadren), atenolol (Tenormin) and nadolol (Corgard).

Triptans: Frovatriptan (Frova), Naratriptan (Amerge) and Zolmitriptan (Zomig).

Antidepressants: Amitriptyline (Vanatrip, Elavil, Endep) and Venlafaxine (Effexor)

Herbal and supplements: Butterbur, magnesium, feverfew and riboflavin.

Nonsteroidal anti-inflammatory drugs (NSAIDs):  Fenoprofen (Nalfon), ibuprofen (Advil, Motrin, etc.), ketoprofen (Actron), naproxen and naproxen sodium (Aleve, Anaprox, etc.)
Histamine injections.

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10 Life-Enhancing Things You Can Do in Ten Minutes or Less

It usually takes us much longer to change our moods than we’d like it to take. Here are ten things you can do in ten minutes or less that will have a positive emotional effect on you and those you love.

1.    Watch “The Last Lecture” by Randy Pausch. See it online at Oprah.com. This is a deeply moving segment that may be the best ten minutes you’ve ever invested in front of a computer.

2.    Spend a little while watching the sunset with your mate. Nothing extra is necessary. Just sit and take in the natural beauty of the sky and appreciate being able to share it with the one you love.

3.    Sit quietly by yourself. It doesn’t really matter where or when. Just let your feelings bubble up and then experience the thoughts flowing out of your mind. Clearing your head and heart will give you extra energy to get through the rest of the day.

4.    Write a thank you note to your mate. When was the last time you thanked your partner for just being who he or she is and being with you? Doing this in writing will give your partner something to cherish for the rest of his or her life.

5.    Take out your oldest family photo album and look through it. The experience will fill you with fond memories and perhaps make you a bit wistful for days gone by.

6.    Play with a child. Most kids have short attention spans; ten minutes of quality time from a loving adult can make their day. It will also help you stay in touch with the child inside of you.

7.    Visualize or imagine a positive outcome for any issue. Medical doctors recommend visualization to patients with chronic and potentially fatal illnesses. If it can help them, it can do the same for you.

8.    Go to bed with the one you love ten minutes earlier than usual. Then spend that time just holding each other. Let the feeling of warmth from your mate move through you.

9.    Hang out by some water. Studies show that hospital patients who can see a natural body of water from their beds get better at a 30 percent faster rate. If you’re not near the coast or a lake, try taking a bath. Doing so is also healing.

10.  Get your body moving. Shake, twist, and jump around. Let yourself feel the joy of moving to your favorite music, or just the sounds in your head. Run, walk, and bike to your hearts content. You will live longer and love it more.

Sadly, many people measure happiness by how long the experience lasts. The truth is that a few minutes of joy here and there can make a big difference in what you get out of life.

 

By Barton Goldsmith, Ph.D.

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Berries keep your brain sharp

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Study finds certain berries may delay memory decline in older women

Jon Chase/Harvard Staff Photographer

“Among women who consumed two or more servings of strawberries and blueberries each week we saw a modest reduction in memory decline. This effect appears to be attainable with relatively simple dietary modifications,” said Harvard researcher Elizabeth Devore of the Channing Laboratory.

Berries are good for you, that’s no secret. But can strawberries and blueberries actually keep your brain sharp in old age? A new study by Harvard researchers at Brigham and Women’s Hospital (BWH) finds that a high intake of flavonoid-rich berries, such as strawberries and blueberries, over time, can delay memory decline in older women by two and a half years. This study was published today by Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society.

“What makes our study unique is the amount of data we analyzed over such a long period of time. No other berry study has been conducted on such a large scale,” said Elizabeth Devore, a researcher in the Channing Laboratoryat BWH, who is the lead author on this study. “Among women who consumed two or more servings of strawberries and blueberries each week we saw a modest reduction in memory decline. This effect appears to be attainable with relatively simple dietary modifications.”

The research team used data from the Nurses’ Health Study — a cohort of 121,700 female, registered nurses between the ages of 30 and 55 — who completed health and lifestyle questionnaires beginning in 1976. Since 1980, participants were surveyed every four years regarding their frequency of food consumption.  Between 1995 and 2001, memory was measured in 16,010 subjects over the age of 70 years, at two-year intervals. Women included in the present study had a mean age of 74 and mean body mass index of 26.

This study, which was independently controlled by the investigators who performed the data analysis, was funded by grants from the National Institutes of Health and the California Strawberry Commission.

Findings show that increased consumption of blueberries and strawberries was associated with a slower rate of memory decline in older women. A greater intake of anthocyanidins and total flavonoids was also associated with reduced memory decline. Researchers observed that women who had higher berry intake had delayed memory decline by up to two and a half years.

“We provide the first epidemiologic evidence that berries appear to slow progression of memory decline in elderly women,” notes Devore, who is an instructor in medicine at Harvard Medical School. “Our findings have significant public health implications as increasing berry intake is a fairly simple dietary modification to reduce memory decline in older adults.”

 

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What is WAT….ERRRR ? LOL…!!!!

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1) What is Water?

Water, W, Hot Ice, Liquid Crystal… all these “street” terms refer to the same substance, known chemically as H20. Water is a highly addictive and toxic chemical, which in its natural state is completely odorless, tasteless,and clear.

2) Is Water dangerous?

Yes. A scientific survey recently concluded that every creature on earth contains Water, and almost every creature imbibes more during its life.
Moreover, every animal that has ever ingested this substance has invariably tried to get more. Organisms unable to get more Water show signs of withdrawal, or “dehydration,” and eventually die. Organisms that ingest more Water inevitably die anyway.
Aside from the biological considerations, remember that Water is composed of Hydrogen and Oxygen, which are used together as rocket fuel. Enough cannot be said about the volatile nature of this chemical.

3) Can I put Water in my bong?

Mixing drugs is never recommended, but if you must attempt this, note the following:

-Water acts as a coolant and filter. You are likely to get larger,smoother hits than normal.

-Water may actually blend into the smoke, imparting its own qualities to the hit.

-Water may splash up and get in your mouth. Yuck.

4) A FOAF got some laced Water. How frequently does this happen?

Almost all Water contains some contaminants. Generally, since Water has no taste or odor, the presence of either of these may indicate foreign substances. Water is so strong, and so cheap to produce, that the story of the dealer who dusted his grass to make it salable doesn’t really apply.

5) How is Water synthesized?

The simplest synthesis is as follows:

-Fill a pot from the kitchen tap.

-Boil for fifteen minutes.

The Water is now suitable for ingestion.

Steve J. Quest gives a more involved recipe yielding a higher-grade
intoxicant:

Preparation of Hydrogen Oxide (Water)
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
An Erlenmeyer flask is first filled with a few grams of zinc metal chips and is then fitted with a two hole rubber stopper. A thistle tube is introduced through one hole and pushed to a level where the end of the tube is just above the zinc chips. A
rubber tube is introduced through the other hole and connected
to a horizontal copper pipe filled with loose fitting chunk
cupric oxide. The other end of the copper pipe is connected to
a Liebig condenser mounted in a distilling fashion (open end
pointing down) which is suspended above a capture beaker.

A bunsen flame is placed under the cupric oxide reaction pipe, and any kind of cold liquid is allowed to circulate through the condenser. (some would use cold tap Water, but I can not recommend that procedure here due to legalities involved.)

Sufficient quantities of concentrated sulfuric acid are then introduced through the thistle tube to completely cover the zinc chips to a level ABOVE the end of the thistle tube. Condensation will start to occur within the condenser and run out into the beaker. The crude product represents a technical grade of
hydrogen oxide, suitable for recreational purposes.

The reaction sequence is as follows:

Zn + H2SO4 -> ZnSO4 + H2 H2 + CuO -> Cu + H2O

6) Is homebrewed “bathtub” Water as effective as “the real thing?”

In the author’s opinion, “bathtub” Water (“slosh”) will never be able to compete with legendary types like Owsley, Naya, and Perrier, but there is of course a certain satisfaction in synthesizing your own.

7) What is ‘kind’ Water?

According to Peter McDermott:

There are actually two major kinds. ‘Soft’ Water and ‘Hard’ Water. The ‘soft’ Water does less damage (to kettles, pipes, etc.)
but the hard Water is a better hit. Some people argue that there is something called a ‘gatevalve’ syndrome,where some people who begin on the relatively harmless ‘soft’ Water are likely to escalate to the hard stuff. However, this isn’t true of everybody.
Personally, I’ve been drinking soft Water for years without ever trying anything harder.

8) Are there different types of Water?

Christopher K. Koenigsberg explains:

There are apparently variations in the chemical makeup of W sold in stores, so someone should look into this for the FAQ (W’s still available over the counter, no prescription necessary, not yet regulated by the FDA, nor scheduled by the DEA, I guess? How much longer before they catch on? Maybe we should be more cautious and not talk about it so openly, before they start having congressional hearings or something?)

For example I’ve seen W labelled “Steam Distilled” but on the same shelf also seen W labelled “Drinking Water” and even “Spring Water”, and a more expensive kind for Babies (yes they are even hooking innocent infants) and there may or may not be differences beyond just the labels and packaging. There are variations in the price even for the same kind of stuff, the local store brand is always the cheapest, regional “Artesian Wells” etc. are more expensive, and the imported kind is most expensive.

There are vending machines outside some grocery stores (hey! you don’t even have to show an ID to prove your age!) which will disburse W either Distilled or for Drinking, into your own choice of unlabelled container (so you can pretend it’s something else). And the Drinking kind supposedly has mineral additives. I don’t know if this is Strychnine, among the additives, which maybe causes the cramps when you drink too much, too fast, or too cold…. but I hear that’s just a myth.

9) What is the LD50 of Water?

TOXICITY DATA
REC-WMN LDLO:180 GM/KG/28H JAMAAP 104,1569,35
IPR-MUS LD50:190 GM/KG NTIS** AD628-313
IVN-MUS LD50:25 GM/KG MIVRA6 8,320,74
REVIEWS, STANDARDS, AND REGULATIONS
NOHS 1974: HZD M1000; NIS 561; TNF 436805; NOS 294; TNE 7313166
NOES 1983: HZD M1000; NIS 500; TNF 313467; NOS 324; TNE 8785413; TFE
3032116
EPA GENETOX PROGRAM 1988, INCONCLUSIVE: B SUBTILIS REC ASSAY
EPA TSCA CHEMICAL INVENTORY, JUNE 1990
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 1993
ADDITIONAL INFORMATION
LD50
4180 MG/KG ( ) ( )
> 99999 MG/KG (IPR-MUS)

CHRONIC EFFECTS
OTHER HEALTH HAZARDS
PRIMARY INFECTIONS OF CYTOMEGALOVIRUS (CMV) ARE USUALLY ASYMPTOMATIC
BUT IN RARE CASES, SUBSEQUENT INFECTIONS MAY CAUSE MONONUCLEOSIS-LIKE
DISEASE. CMV CAN ALSO RESULT IN LATENT INFECTIONS AND HAS BEEN
IMPLICATED IN CERTAIN TYPES OF CANCER.

This is of course in mice and may not apply directly to humans. W can be very dangerous, so play nice and be safe.

APPENDIX 1: Descriptions of Water ‘trips’ and usage

Kevin Jernigan, alt.drugs #85634:

I drank Water for the first time at a party last night, and it was great!!
Some of my friends who do W told me about the experience earlier, but I now realize that it was beyond my wildest expectations. I was a little bit scared, at first, because I heard about some of the bad side effects that it can cause. A few people said they choked on it, and one guy said that he dribbled it all
over his clothes and got them wet. Luckily, none of these things happened to me. They started passing glasses around to everyone and I decided to take one. The Water was very clear in color. They said it was scored from a guy who got it from a spring in Canada. I don’t know whether it was really Canadian Water, but it was definitely good quality, judging by the color. I used about 500g of it. When I put the glass up to my mouth, and swallowed, the
first sensation I felt was of something wet traveling down my throat. This sensation started before I had even removed the glass from my mouth. I was able to acheive the same feeling again, by taking another swallow. As the trip progressed, I noticed several other things. The W produced a state of mind that I believe could best be described as a lack of thirst. The trip
didn’t last for very long, but I think that it would be safe to say that the experience gave me some important insights into my consciousness. Chief among these, is the realization that Water can relieve thirst.

Ray Mialki, email contribution:

Although I don’t partake, some of my neighbours down quite a bit of the stuff, filling swimming pools and such. I use it in great moderation, not even having an outside hose spigot to wash the car with. Daily showers seem to be my habitual use.

Peter McDermott, alt.drugs #unknown:

A recent major survey (n=1) has showed that Water addiction runs in families. At present, NIDA funded scientists are working flat out on the genesis of this crippling condition.

Unlike other addictions, W abuse is believed to affect all sections of society, rich and poor alike. However, scientists have discovered that a gene may well be responsible for a predisposition to drinking W.

Although 12 step ‘W’ recovery programmes have been around for some time now, major cities have begun to witness a growth in self-help programs for Adult Children of Waterholics. “Henry” is a member of such a group.

“Well, I’ve just got so much rage about this, y’know? I was never able to confront them about it at the time. I thought that drinking Water was normal. Now I’m angry. Ours is a sick culture. The French would never dream of exposing their children to ‘W’ at dinner. There, the kids go from breast milk to wine. But every single day, there it was, sitting at the dinner table in front of me. Of course, they wouldn’t let me have any, but after watching them do it, I saw where they got it from. I began sneaking to the tap, and taking a sip. Before I knew where I was
I was into the hard stuff – you know, Water sports. Baths, showers, stuff like that.

Well, eventually, I hit bottom. I out in town and the craving came on me and I found myself licking it up from puddles. Then it was toilet bowls. There are no wells too deep for the ‘W’ addict. So I went and got help. I’ve been in recovery for like.. 3 days now, but I wasn’t making any progress. Then my therapist told me about A CoW and since then, it’s been nothing but milk. And not mother’s milk either…”

However, not everybody accepts that ‘W’ use is a problem. ‘Mary’ has been using ‘W’ for a month now. She feels that the dangers of ‘W’ have been much exaggerated.

“It’s all propaganda, isn’t it? I’ve been doing ‘W’ for ages now, and it’s just a bit of a buzz, innit. It’s harmless man. There isn’t a single study that *proves* ‘W” has any effect on the bladder, and as for people who say it makes you piss. Well, they are just dirty minded.
As I said, I’ve been doing ‘W’ for a month, and I’ve never had a piss, ever.

We’ve started a pressure group called ‘Fair Play for Water’ and it’s our aim to force the government to tell the truth about ‘W’. If there are risks, tell us what they are, and how we can minimize them. Prohibition doesn’t work. The government knows that. Why else would they have repealed the laws against heroin and cocaine? Unfortunately, there are political careers to be made out of that issue. Vote Libertarian. Privatise the Water companies. Stop all government regulation of Water now!!!!

APPENDIX 2: Street Prices, June 4, 1993

Chicago, IL, North Shore Area
-Typical Naya, $1 US per liter.

Springdale Township, Pennsylvania
$5 per 1000 gallons.

APPENDIX 3: International Legality Update

In Europe W is becoming something of a threat real fast. I myself have witnessed tourists trying to score W desperately the last couple of hot days here this week. As of yet there is no shortage of W, but I’ve heard that in Greece it’s getting scary.
The police are starting to recognise this situation and have called for more forces on the street, weeding out W-pushers and sentencing them to severe punishments straight away!

APPENDIX 4: Contributors

Kevin Jernigan ([email protected])
Ray Mialki ([email protected])
Steve J. Quest ([email protected])
Peter McDermott ([email protected])
Christopher K. Koenigsberg ([email protected])

And to all you whose headers got chopped, my apologies.

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Anxiety Increases Cancer Severity in Mice, Study Shows

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Worrywarts, fidgety folk and the naturally nervy may have a real cause for concern: accelerated cancer. In a new study led by researchers at the Stanford University School of Medicine, anxiety-prone mice developed more severe cancer then their calm counterparts.

The study, published online April 25 in PLoS ONE, found that after hairless mice were dosed with ultraviolet rays, the nervous ones — with a penchant for reticence and risk aversion — developed more tumors and invasive cancer. Consistent anxiety also came with sensitivity to chronic stress and a dampened immune system. Though other researchers have already linked chronic stress to higher risks for cancer and other maladies, the study is the first to biologically connect the personality trait of high anxiety to greater cancer threats.
“Anxiety may be defined as increased sensitivity to physically existent, or non-existent but perceived or anticipated, stressors,” said stress expert and immunologist Firdaus Dhabhar, PhD, first author of the study.
Dhabhar’s previous work has investigated the balance of “good” and “bad” stress. Short-lived stressors — like being chased by a lion, or giving a weighty presentation to your boss — can actually boost your immune system by preparing your body for battle. But constant stress, such as caring for a disabled loved one, breaks down the body’s ability to fight off disease over time, he said.
The question is: How much stress is too much? Because stress responses vary between individuals, Dhabhar turned to understanding the link between base-level anxiety and actual stress.
For mice, stress comes from striking a balance between exploring to find food and mates, and protecting themselves from danger. Highly anxious mice, Dhabhar hypothesized, would err on the side of avoiding danger. He and his research team placed hairless mice on a raised, cross-shaped track, which had one walkway enclosed by walls and the other open. Then they measured how often each mouse ventured to the open arms. Likewise, he placed them in a large box, half lit and half dark, and noted those that spent the most time in the dark side.
“It’s similar to the idea that if someone is very anxious they may be more worried about, and less likely to, walk down a dark alley,” said Dhabar, an associate professor of psychiatry and behavioral sciences and a member of the Stanford Cancer Institute and the Stanford Institute for Immunity, Transplantation and Infection.
With their evaluation of anxiety complete, the researchers exposed all the hairless mice to UV rays for 10-minute bouts, three times a week, for 10 weeks — exposure similar to that of humans who spend too much time in the sun. Tumors cropped up a few months afterward. “This skin cancer model is really valuable,” Dhabhar said, “because it closely mimics human skin cancer.”
Additionally, these types of tumors are vulnerable to an immune system attack. In some cases, the immune system could destroy them, he said.
Though all the mice eventually developed skin cancer, the anxious mice had more tumors and were the only ones to develop invasive forms of cancer.
When he and his team compared the immune responses of the low- and high-anxiety mice, they found that nervous mice had higher levels of immune-suppressing cells called regulatory T cells, which normally thwart overzealous responses. The high-strung mice were also making fewer of the chemical signals that fire up an immune attack on the tumors.
Lastly, the researchers looked at the hormone corticosterone. In mice and other animals, the adrenal system — the “fight or flight” controller of the body — secretes corticosterone in response to disease and stress. The levels of this hormone were cranked up in anxious mice, suggesting that they have more sensitive stress sensors and, perhaps, a lower threshold for feeling under the gun.
“Identifying a psychological trait right at the beginning — before any experimental manipulation — and seeing that it can be associated with increased tumors months later, and with biology that can begin to explain mechanisms, was a rewarding surprise,” Dhabhar said.
This hasn’t been tested in humans yet, and that needs to be done, Dhabhar said.
“It’s bad enough that cancer diagnosis and treatment generates stress and anxiety, but this study shows that anxiety and stress can accelerate cancer progression, thus perpetuating a vicious cycle,” Dhabhar said. “The goal is to ameliorate or eliminate the effects of anxiety and chronic stress, at least at the time of cancer diagnosis and during treatment.”
The team’s next step will be examining whether knocking down the negative effects of anxiety and stress can increase the benefits of cancer treatment. A shot of anxiety medication, such as Valium, for limited periods of time may be helpful, Dhabhar said. There may also be combinations of drugs and behavioral changes that could be most effective in the long run. “Ultimately,” he said, “we really want to harness the patient’s mind and body while doing everything that medicine can from the outside to maximize treatment success.”
Other Stanford co-authors include Tyson Holmes, PhD, senior research scientist; Eric Neri, database manager and analyst; and Jean Tillie, life science research assistant. The team also collaborated with researchers at the University of Texas and the Ohio State University College of Medicine.
The work was supported by the National Cancer Institute.

Story Source:

The above story is reprinted from materials provided byStanford University Medical Center. The original article was written by Beth Mole.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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When you think things are out of control…

When things get out of control and you momentarily lose your emotional balance, there are any number of little things you can do to regain it. Here are ten tools to help get you started.

1. Wash your hands and face and brush your teeth. It cools and cleans the parts of your body that you use most frequently, which is relaxing, and gives you that “fresh start” feeling.
2. Put on clean socks and some shoes that you haven’t worn in a few days. Shoes take a day or two to release any moisture they have absorbed, and this is a very easy way to put a little pep back into your step.
3. Give yourself a good shave (face or legs). This is another instant refresher. Especially if you have sensitive skin or the weather is dry. Plus, when we know we are looking our best, we naturally feel better.
4. Look at any trophy, diploma, or certificate of achievement that you have earned. And if it isn’t framed and on the wall, frame it now. These are reminders of your accomplishments, and taking in your success is important to maintaining your self-esteem.

5. Remember your last (or greatest) success and think about it for sixty seconds. Taking in your success as often as possible will help you reach another and another. Quite simply, it reminds you that if you’ve done it before, you can do it again.
6. Know you are the person your loved ones think you are. And yes, that goes for your dog too. Knowing that you are unconditionally loved can’t help but make you feel good about yourself. It’s so easy to beat yourself up, I recommend pulling yourself up instead.
7. Wash your car, inside and out. Hey, when our wheels are shiny, we feel better. If you don’t think this applies to you, just remember how you felt the last time you got a ride in someone’s very funky car. Race you to the car wash.
8. Organize your closet and get rid of anything that no longer fits. Old clothes may come back into style, but you really don’t want them on hangers for the next twenty years. Throwing out the old makes room for the new. For some, the feeling they get from putting on a new “power suit” fills them with pride.
9. Cook a lovely meal. Even if you are by yourself, preparing a tasty dinner, setting the table, and treating yourself to a wonderful culinary experience will lift your spirits. Sharing it with someone you love and/or respect will make it even more nurturing.
10. Look around you, remember that you started with nothing, and know that everything you see, you created. We can all lose our feelings of self-worth, especially when something goes wrong in our world. The truth is that if you have done it before, you can do it again-no matter what.

None of these tasks has to be uncomfortable or take you much time. Finding ways to give yourself a little boost when you’re not feeling like you’re at the top of your game is a trick that truly happy people use on a regular basis.

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Don’t pray in my school and Others…!!!

An atheist is a man who has no invisible means of support.– John Buchan, 1875-1940

 

Isn’t it enough to see that a garden is beautiful without having to believe that there are fairies at the bottom of it too?– Douglas Adams
The Hitch Hiker’s Guide to the Galaxy, chapter 16. 1979

 

So atheists disbelieve in all gods, while monotheists disbelieve in all but one. Thus the atheists have both consistency and the razor working for them. Seems like a more rational position to me.
IIRC the Romans called early Christians atheists since they disbelieved in so many gods.– William Hyde, rec.arts.sf.written, April 2000

 

In my notes, I have the line:
Ataraxia: (Greek): The state of tranquillity achieved by ignoring all the bullshit you are told.– Andrew Plotkin, rec.arts.sf.written, April 2000
during a discussion about the meaning of “atheist” versus “agnostic”

[The Complete OED defines it more prosaically:
ataraxia: Freedom from disturbance of mind or passion; stoical indifference]

It takes a very special and strong-minded kind of atheist to jump up and down with their hand clasped under their other armpit and shout, ‘Oh, random-fluctuations-in-the-space-time-continuum!’ or ‘Aaargh, primitive-and-outmoded-concept on a crutch!’– Terry Pratchett

 

I contend that we are both atheists. I just believe in one fewer god than you do. When you understand why you dismiss all the other possible gods, you will understand why I dismiss yours.– Stephen F Roberts
alt.atheism or talk.atheisim, 1994 or 1995
http://freelink.wildlink.com/quote_history.php

Therefore, in regard to the Olympic gods, speaking to a purely philosophical audience, I would say that I am an Agnostic. But speaking popularly, I think that all of us would say in regard to those gods that we were Atheists. In regard to the Christian God, I should, I think, take exactly the same line.There is exactly the same degree of possibility and likelihood of the existence of the Christian God as there is of the existence of the Homeric God. I cannot prove that either the Christian God or the Homeric gods do not exist, but I do not think that their existence is an alternative that is sufficiently probable to be worth serious consideration.

Bertrand Russell
Am I An Atheist Or An Agnostic? A Plea For Tolerance In The Face Of New Dogmas, 1947

 

Many orthodox people speak as though it were the business of sceptics to disprove received dogmas rather than of dogmatists to prove them. This is, of course, a mistake. If I were to suggest that between the Earth and Mars there is a china teapot revolving about the sun in an elliptical orbit, nobody would be able to disprove my assertion provided I were careful to add that the teapot is too small to be revealed even by our most powerful telescopes. But if I were to go on to say that, since my assertion cannot be disproved, it is intolerable presumption on the part of human reason to doubt it, I should rightly be thought to be talking nonsense. If, however, the existence of such a teapot were affirmed in ancient books, taught as the sacred truth every Sunday, and instilled into the minds of children at school, hesitation to believe in its existence would become a mark of eccentricity and entitle the doubter to the attentions of the psychiatrist in an enlightened age or of the Inquisitor in an earlier time.– Bertrand Russell, Is There a God?, 1952
commissioned by Illustrated Magazine,
first published in The Collected Papers of Bertrand Russell, Volume 11: Last Philosophical Testament, 1943-68,
ed. John G. Slater and Peter Köllner, pp. 543-48, 1997

 

If atheism is a faith, then not playing chess is a hobby.– New Scientist2589:21, 3 February 2007

 

I’m a born-again atheist.– Gore Vidal (1925–)

 

I’m what’s called here a “secular atheist,” except that I can’t even call myself an “atheist” because it is not at all clear what I’m being asked to deny.– Noam Chomsky,
Beyond Belief: Science, Religion, Reason and Survival, 2006

 

Is god willing to prevent evil, but not able? Then he is not omnipotent. Is he able but not willing? Then he is malevolent. Is he both able and willing? Then whence cometh evil? Is he neither able nor willing? Then why call him god?– Epicurus (341 BC–270 BC) attrib

My practice as a scientist is atheistic. That is to say, when I set up an experiment I assume that no god, angel, or devil is going to interfere with its course; and this assumption has been justified by such success as I have achieved in my professional career. I should therefore be intellectually dishonest if I were not also atheistic in the affairs of the world.

— J. B. S. Haldane,
Preface to Fact and Faith, 1934

Don’t pray in my school; i won’t think in your church……………..!!!!!!

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Silly Chem Jokes

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1. Two atoms are walking down the street.

Says one atom to the other, “Hey! I think I lost an electron!”

The other says, “Are you sure??”

“Yes, I’m positive!”

 

2. If you’re not part of the solution, you’re part of the precipitate!

 

3. A neutron walks into a restaurant and orders a couple of cokes. As she is about to leave, she asks the waiter how much she owes.  The waiter replies, “For you, No Charge!!!”

 

4. A sign outside the chemistry hotel reads “Great Day Rates,  Even Better NO3‘s”

 

5. Sometimes people can get carried away with a danger that isn’t real!  A group is working hard to ban the “potentially dangerous” chemical,  dihydrogen monoxide (water) – check out the research on this subject.

 

6. A small piece of ice which lived in a test tube fell in love with a Bunsen burner. “Bunsen! my flame! I melt whenever I see you” said the ice. The Bunsen burner replied :”It’s just a phase you’re going through”.

 

7. Heisenberg is out for a drive when he’s stopped by a traffic cop. The cop says: ” Do you know how fast you were going? Heisenberg replies: “No, but I know where I am”.

 

8. Why did the white bear dissolve in water?   Because it was polar.

 

9. What do you call a tooth in a glass of water?  A one molar solution.

 

10.  What do dipoles say in passing?  “Have you got a moment?”

 

11. Why does hamburger have lower energy than steak?   Because it’s in the ground state.

 

12. What do you do with a dead chemists?  Barium

 

13. What weapon can you make from the elements potassium, nickel and iron?  A KNiFe.

 

14. What did one titration tell the other?  Let’s meet at the endpoint.

 

15. Why are chemists great for solving problems?   They have all the solutions.

 

16. Did you hear about the chemist who was reading a book about Helium?  He just couldn’t put it down.

 

17. Why do chemistry professors like to teach about ammonia?  Because it’s basic material.

 

18. What is a cation afraid of?  A dogion.

 

19. What did the Cowboy Chemist tell his horse?  HIO Ag!!!!

 

20. How many moles are in a guacamole? Avocado’s number.

 

21. Why did Carbon marry Hydrogen?  They bonded well from the minute they met.

 

22. What kind of ghosts haunt chemistry faculties?  Methylated spirits.

 

23.  If H20 is water what is H204?  Drinking, bathing, washing, swimming. . .

 

24.  According to a chemist, why is the world so diverse?  Because it’s made up of alkynes of people.

25. What’s the difference between Chemistry and cooking?  In Chemistry, you should never lick the spoon.

26. A group of organic molecules were having a party, when a group of robbers broke into the room and stole all of the guest’s joules.  A tall, strong man, armed with a machine gun came into the room and killed the robbers one by one. The guests were very grateful to this man, and they wanted to know who he was. He replied: My name is BOND, Covalent Bond.

27. A freshman chemistry student prepared a standard solution and showed it to her professor. The professor gave her a puzzled look, and said: This solution looks a bit WEIRD. Are you sure you used the right set of reagents? The student replied: Absolutely. According to my calculations, this is one NORMAL solution.

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